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8/25/2014 2:47:00 PM | Browse: 1005 | Download: 1002
Publication Name World Journal of Gastroenterology
Manuscript ID 5986
Country/Territory Poland
Received
2013-10-03 17:27
Peer-Review Started
2013-10-04 16:02
To Make the First Decision
2013-12-26 10:49
Return for Revision
2013-12-27 15:49
Revised
2014-01-17 19:44
Second Decision
2014-04-23 09:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-23 10:05
Articles in Press
2014-05-23 11:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-05-08 23:10
Typeset the Manuscript
2014-07-20 14:13
Publish the Manuscript Online
2014-08-07 10:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years
Manuscript Source Invited Manuscript
All Author List Mariusz Panczyk
Funding Agency and Grant Number
Corresponding Author Mariusz Panczyk, PharmD, PhD, Division of Teaching and Outcomes of Education, Faculty of Health Science, Medical University of Warsaw, Zwirki i Wigury 61, 02-091 Warsaw, Poland. mariusz.panczyk@wum.edu.plTelephone: +48-22-5720490
Key Words Pharmacogenetics; Pharmacogenomics; Drug resistance; Colorectal cancer; Chemoresistance; Individualized medicine
Core Tip Insufficient effectiveness of chemotherapy is still the most important factor limiting the successful treatment of patients with colorectal cancer (CRC). Drug resistance in anticancer therapy has been recognized virtually from the very beginning, as cytostatic drugs were first used in oncology practice. Intensive research on the causes of low sensitivity in colorectal cancer cells to such drugs as fluoropyrimidines, irinotecan and oxaliplatin, has resulted in evidence on the importance of genetic factors in phenotype conditioning of drug resistance. This review is a synthetic presentation of drug resistance in the context of its role in chemotherapy, and the potential clinical use of different biomarkers in individualization of CRC patient treatment.
Publish Date 2014-08-07 10:34
Citation Panczyk M. Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years. World J Gastroenterol 2014; 20(29): 9775-9827
URL http://www.wjgnet.com/1007-9327/full/v20/i29/9775.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i29.9775
Full Article (PDF) WJG-20-9775.pdf
Full Article (Word) WJG-20-9775.doc
Manuscript File 5986-Review.docx
Answering Reviewers 5986-Answering reviewers.pdf
Copyright License Agreement 5986-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 5986-Language certificate.pdf
Peer-review Report 5986-Peer reviews.pdf
Scientific Editor Work List 5986-Scientific editor work list.doc