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9/11/2014 8:39:00 PM | Browse: 656 | Download: 661
Publication Name World Journal of Gastroenterology
Manuscript ID 5988
Country/Territory China
Received
2013-09-29 14:58
Peer-Review Started
2013-09-30 16:32
To Make the First Decision
2013-10-14 20:57
Return for Revision
2013-10-15 11:27
Revised
Second Decision
2013-11-18 21:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-19 12:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-11-26 21:50
Typeset the Manuscript
2013-12-18 09:14
Publish the Manuscript Online
2014-01-20 16:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Topic Highlights
Article Title Antiviral treatment of hepatitis C virus infection and factors affecting efficacy
Manuscript Source Invited Manuscript
All Author List Yan Zhu and Song Chen
Funding Agency and Grant Number
Corresponding Author Dr. Song Chen, Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Shapingba District, Chongqing 400038, China. cs196@medmail.com.cn
Key Words Hepatitis C virus; Treatment; Interferon; Protease inhibitors; IL28B protein; Polymorphisms; Viral load; Genotype; Hepatic steatosis
Core Tip Understanding the effectiveness and affecting factors of antiviral regimens are critical for making informed treatment decisions for hepatitis C virus (HCV) infection. In this review, we have summarized the history of anti-HCV agents from interferon to the direct-acting antiviral drugs (DAAs) without polyethylene glycol interferon-? therapies and the affecting factors of antiviral treatment, focusing on investigating the optimal combination of antiviral therapies to achieve higher efficacy and better medication compliance. Although the efficacy of DAAs is significantly improved, many unmet needs and questions remain, such as avoidance of cross-resistance, the remaining high incidence of side effects, the role of IL28B status as well as the management of patients who do not respond to therapy.
Publish Date 2014-01-20 16:41
Citation Zhu Y, Chen S. Antiviral treatment of hepatitis C virus infection and factors affecting efficacy. World J Gastroenterol 2013; 19(47): 8963-8973
Url http://www.wjgnet.com/1007-9327/full/v19/i47/8963.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i47.8963
Full Article (PDF) WJG-19-8963.pdf
Manuscript File 5988-Review.doc
Answering Reviewers 5988-Answering reviewers.pdf
Copyright License Agreement 5988-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 5988-Language certificate.pdf
Peer-review Report 5988-Peer review(s).pdf
Scientific Editor Work List 5988-Scientific editor work list.doc