Publication Name	World Journal of Psychiatry
Manuscript ID	59956
Country	China

Received	2020-10-13 08:04
Peer-Review Started	2020-10-13 08:04
To Make the First Decision
Return for Revision	2020-12-04 02:36
Revised	2020-12-09 04:53
Second Decision	2020-12-24 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-12-25 05:18
Articles in Press	2020-12-25 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-12 21:14
Typeset the Manuscript	2021-01-20 12:18
Publish the Manuscript Online	2021-01-26 06:58

ISSN	2220-3206 (online)
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Category	Psychiatry
Manuscript Type	Basic Study
Article Title	Selective ablation of type 3 adenylyl cyclase in somatostatin positive interneurons produces anxiety- and depression-like behaviors in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Yu Yang, Zhao-Liang Ma, Daniel R Storm, Hong Cao and Yu-Qiu Zhang
ORCID	Author(s) ORCID Number Xiao-Yu Yang http://orcid.org/0000-0002-5178-1930 Zhao-Liang Ma http://orcid.org/0000-0002-0478-1452 Daniel R Storm http://orcid.org/0000-0001-6695-2379 Hong Cao http://orcid.org/0000-0001-5048-3379 Yu-Qiu Zhang http://orcid.org/0000-0001-6623-9629
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81771208 National Natural Science Foundation of China 81971043
Corresponding Author	Hong Cao, MD, PhD, Associate Professor, Department of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institutes of Integrative Medicine, Fudan University, Rm 1202 Mingdao Building, No. 131 Dong'an Road, Shanghai 200032, China. hongcao@fudan.edu.cn
Key Words	Type 3 adenylyl cyclase; Somatostatin; Parvalbumin; Anxiety; Depression; Mice
Core Tip	Dysfunction of cortical GABAergic interneurons are thought to contribute to the pathophysiology of stress-related psychiatric disorders. Little is known about the regulation of GABAergic interneurons in depression. Type 3 adenylyl cyclase (AC3) is important for the neuronal excitability and was reported as a top-ranked gene in major depressive disorder (MDD). Here, we found that majority of somatostatin-positive (SST+) and parvalbumin-positive (PV+) GABAergic interneurons express AC3. Selective disruption of AC3 in SST+ but not PV+ interneurons caused anxiety and depression-like behaviors. Our data suggest that AC3 in specific subtype interneurons played a key role in the etiology of depression, providing new insights for therapeutic interventions for the treatment of MDD.
Publish Date	2021-01-26 06:58
Citation	Yang XY, Ma ZL, Storm DR, Cao H, Zhang YQ. Selective ablation of type 3 adenylyl cyclase in somatostatin positive interneurons produces anxiety- and depression-like behaviors in mice. World J Psychiatr 2021; 11(2): 35-49
URL	https://www.wjgnet.com/2220-3206/full/v11/i2/35.htm
DOI	https://dx.doi.org/10.5498/wjp.v11.i2.35

Full Article (PDF)	WJP-11-35.pdf
Full Article (Word)	WJP-11-35.docx
Manuscript File	59956-Review-FilipodiaCL.docx
Answering Reviewers	59956-Answering reviewers.pdf
Audio Core Tip	59956-Audio core tip.m4a
Biostatistics Review Certificate	59956-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	59956-Conflict-of-interest statement.pdf
Copyright License Agreement	59956-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	59956-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	59956-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	59956-Language certificate.pdf
Peer-review Report	59956-Peer-review(s).pdf
Scientific Misconduct Check	59956-Bing-Gao CC-1.jpg
Scientific Misconduct Check	59956-Scientific misconduct check.pdf
Scientific Editor Work List	59956-Scientific editor work list.pdf