| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cyrla Zaltman, Rogério Serafim Parra, Ligia Yukie Sassaki, Genoile Oliveira Santana, Maria de Lourdes Abreu Ferrari, Sender J Miszputen, Heda M B S Amarante, Roberto Luiz Kaiser Junior, Cristina Flores, Wilson R Catapani, José Miguel Luz Parente, Mauro Bafutto, Odery Ramos, Carolina D Gonçalves, Isabella Miranda Guimaraes, Jose J R da Rocha, Marley R Feitosa, Omar Feres, Rogerio Saad-Hossne, Francisco Guilherme Cancela Penna, Pedro Ferrari Sales Cunha, Tarcia NF Gomes, Rodrigo Bremer Nones, Mikaell Alexandre Gouvea Faria, Mírian Perpétua Palha Dias Parente, António S Scotton, Rosana Fusaro Caratin, Juliana Senra and Júlio Maria Chebli |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Takeda Pharmaceuticals Brazil |
|
|
| Corresponding Author |
Cyrla Zaltman, MD, PhD, Associate Professor, Internal Medicine, Rio de Janeiro Federal University, Rua Rodolpho Paulo Rocco, 255-4o Andar-Cidade Universitária-Ilha do Fundão, Rio de Janeiro 21941-913, Brazil. c.zaltman@gmail.com |
| Key Words |
Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis; Disease activity; Epidemiology; Treatment |
| Core Tip |
In this multicenter study from Brazil, a substantial proportion (45%, and less pronounced in the South) of Crohn’s disease patients had active disease despite being treated with biologics and immunosuppressors. One-quarter (higher in the Northeast/Midwest region) of ulcerative colitis patients had active disease, with the majority treated with 5-Aminosalicylic acid derivatives. In the largest Latin American country, regional differences were observed regarding inflammatory bowel diseases (IBD) activity and treatment patterns. Findings from this study can further elucidate about variations in clinical practice, ultimately promoting debate among specialists regarding the optimal management of IBD patients. |
| Publish Date |
2021-01-11 13:20 |
| Citation |
Zaltman C, Parra RS, Sassaki LY, Santana GO, Ferrari MLA, Miszputen SJ, Amarante HMBS, Kaiser Junior RL, Flores C, Catapani WR, Parente JML, Bafutto M, Ramos O, Gonçalves CD, Guimaraes IM, da Rocha JJR, Feitosa MR, Feres O, Saad-Hossne R, Penna FGC, Cunha PFS, Gomes TNF, Nones RB, Faria MAG, Parente MPPD, Scotton AS, Caratin RF, Senra J, Chebli JM. Real-world disease activity and sociodemographic, clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil. World J Gastroenterol 2021; 27(2): 208-223 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i2/208.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i2.208 |
