| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Faraz Bishehsari, Mahboobeh Mahdavinia, Michele Vacca, Reza Malekzadeh and Renato Mariani-Costantini |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Institutional NRSA, clinical oncology research training program |
T32 CA079447 (Bishehsari F) |
| Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan |
to Mariani-Costantini R |
| Office for Internationalization, G. d’Annunzio University, Chieti |
|
| Carichieti Foundation, Chieti |
|
| Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR), Rome, Italy |
|
| Fondazione Umberto Veronesi, Milan, Italy |
|
| MRC (5PT57) |
to Vacca M |
|
| Corresponding Author |
Faraz Bishehsari, MD, PhD, Division of Gastroenterology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Superior Street, Lurie 3-250, Chicago, IL 60611, United States. faraz-bishehsari@fsm.northwestern.edu |
| Key Words |
Colorectal cancer; Developing countries; Environment; Diet; Nuclear receptors; Gut microbiota |
| Core Tip |
This highlight addresses the rise of colorectal cancer (CRC) in the developing countries. We review the epidemiological data on the growing CRC burden in these countries, discuss the role of changing environmental risk factors, and examine preventive strategies that could contribute to control the spread of CRC. The molecular pathways of CRC and the roles of nuclear receptors and of the intestinal microbiota are discussed in the light of the current epidemiological transition. |
| Publish Date |
2014-05-28 11:45 |
| Citation |
Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R, Mariani-Costantini R. Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol 2014; 20(20): 6055-6072 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i20/6055.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i20.6055 |
