| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Luis Antonio Díaz, Francisco Idalsoaga, Macarena Cannistra, Roberto Candia, Daniel Cabrera, Francisco Barrera, Alejandro Soza, Rondell Graham, Arnoldo Riquelme, Marco Arrese, Michael D Leise and Juan Pablo Arab |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chilean Government Through the Fondo Nacional de Desarrollo Científico y Tecnológico |
1200227 |
| Chilean Government Through the Fondo Nacional de Desarrollo Científico y Tecnológico |
1191183 |
| Chilean Government Through the Fondo Nacional de Desarrollo Científico y Tecnológico |
1191145 |
| Comisión Nacional de Investigación Científica y Tecnológica (CONICYT, CARE Chile UC) |
AFB170005 |
| European Union’s Horizon 2020 Research |
825510 |
|
| Corresponding Author |
Juan Pablo Arab, MD, Assistant Professor, Department of Gastroenterology, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Departamento de Gastroenterología, Santiago 8320000, Chile. jparab@med.puc.cl |
| Key Words |
Pathology; SARS-CoV-2; COVID-19; Autopsies; Liver; Liver biopsies |
| Core Tip |
In this systematic review of 18 studies, we identified that hepatic steatosis, congestion of hepatic sinuses, and vascular thrombosis are the main histological findings in deceased coronavirus disease 2019 (COVID-19) patients. Fibrosis is a common histological finding in deceased COVID-19 patients. Kupffer cell hyperplasia, portal inflammation, and lobular inflammation are related to the severe acute respiratory syndrome coronavirus 2 inflammatory process and are frequent histological findings. Other vascular abnormalities (such as venous outflow obstruction, phlebosclerosis of the portal vein, herniated portal vein, periportal abnormal vessels) are frequent histological finding in deceased COVID-19 patients. |
| Publish Date |
2020-12-25 10:20 |
| Citation |
Díaz LA, Idalsoaga F, Cannistra M, Candia R, Cabrera D, Barrera F, Soza A, Graham R, Riquelme A, Arrese M, Leise MD, Arab JP. High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data. World J Gastroenterol 2020; 26(48): 7693-7706 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i48/7693.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i48.7693 |
