| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Dong Zhao, Yan Li, Min Sun, Chan-Juan Yu, Jia-Yun Li, Si-Hai Wang, Di Yang, Cheng-Lin Guo, Xue Du, Wen-Jin Zhang, Ruo-Dong Cheng, Xiao-Chuan Diao and Zhao-Hui Fang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81603574 |
| National Natural Science Foundation of China |
81774286 |
| National Key Research and Development Program |
2018YFC1704202 |
| National Key Research and Development Program |
2020YFE0201800 |
| University Scientific Research Projects of Anhui |
KJ2019A0442 |
| Province Science Foundation of Anhui |
1708085QH213 |
|
| Corresponding Author |
Zhao-Hui Fang, PhD, Chief Doctor, Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei 230031, Anhui Province, China. fangzhaohui1111@163.com |
| Key Words |
Type 2 diabetes mellitus; Amelioration of hyperglycaemia; Modulation of gut microbiota; Berberine; Metformin; Goto-Kakizaki rats |
| Core Tip |
Recent studies suggested that the gut microbiota has an essential role in type 2 diabetes mellitus. Our study verifies the effects of berberine in regulating glucose metabolism and reducing pancreas injury in Goto-Kakizaki rats. Berberine also provides an alternative means of modulating the gut microbiota. Results revealed evidence of a decrease in Desulfobacterota, Desulfovibrionaceae and Clostridia_UCG-014 and an increase in Verrucomicrobiota, Akkermansia and Allobaculum. The correlation analysis indicated that fasting blood glucose was strongly positively correlated with Clostridia_UCG-014 and negatively correlated with Allobaculum. |
| Publish Date |
2021-02-26 05:58 |
| Citation |
Zhao JD, Li Y, Sun M, Yu CJ, Li JY, Wang SH, Yang D, Guo CL, Du X, Zhang WJ, Cheng RD, Diao XC, Fang ZH. Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats. World J Gastroenterol 2021; 27(8): 708-724 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i8/708.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i8.708 |
