Publication Name	World Journal of Gastroenterology
Manuscript ID	60344
Country	China

Received	2020-11-07 03:38
Peer-Review Started	2020-10-30 11:58
To Make the First Decision
Return for Revision	2020-12-03 06:30
Revised	2020-12-14 08:45
Second Decision	2021-01-30 13:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-02-01 21:51
Articles in Press	2021-02-01 21:51
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-02-20 00:44
Typeset the Manuscript	2021-03-01 01:14
Publish the Manuscript Online	2021-03-03 10:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Abdominal paracentesis drainage attenuates intestinal inflammation in severe acute pancreatitis rats through inhibiting the HMGB1-mediated TLR4 signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Shang-Qing Huang, Yi Wen, Hong-Yu Sun, Jie Deng, Yao-Lei Zhang, Qi-Lin Huang, Bing Wang, Zhu-Lin Luo and Li-Jun Tang
ORCID	Author(s) ORCID Number Shang-Qing Huang http://orcid.org/0000-0003-1420-9537 Yi Wen http://orcid.org/0000-0002-1426-6833 Hong-Yu Sun http://orcid.org/0000-0003-0000-0000 Jie Deng http://orcid.org/0000-0003-3809-4930 Yao-Lei Zhang http://orcid.org/0000-0002-2133-5120 Qi-Lin Huang http://orcid.org/0000-0002-0819-4829 Bing Wang http://orcid.org/0000-0003-3064-6147 Zhu-Lin Luo http://orcid.org/0000-0003-3554-1846 Li-Jun Tang http://orcid.org/0000-0001-6000-9515
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81772001 National Clinical Key Subject of China 41732113 Technology Plan Program of Sichuan Province 2019JY0277 Technology Plan Program of Sichuan Province 2020YFSY0022
Corresponding Author	Li-Jun Tang, MD, PhD, Chief Doctor, Professor, Department of General Surgery & Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command (Chengdu Military General Hospital), No. 270 Rongdu Road, Jinniu District, Chengdu 610083, Sichuan Province, China. tanglj2016@163.com
Key Words	Abdominal paracentesis drainage; Severe acute pancreatitis; High mobility group box 1; Toll-like receptor 4; Nuclear factor-κB
Core Tip	We provide the first evidence that abdominal paracentesis drainage (APD) plays a protective role in intestinal inflammation and accompanying apoptosis induced by severe acute pancreatitis (SAP). Our key findings were: (1) APD decreased serum levels of indexes related to intestinal injury and improved intestinal barrier function; (2) APD alleviated intestinal inflammation and accompanying mucosal cell apoptosis; and (3) the beneficial effects of APD in ameliorating intestinal injury were due to suppressed activation of intestinal toll-like receptor 4/nuclear factor-κB signaling pathway mediated by high mobility group box protein 1. We elucidated the molecular mechanism behind APD treatment of SAP and its complications.
Publish Date	2021-03-03 10:02
Citation	Huang SQ, Wen Y, Sun HY, Deng J, Zhang YL, Huang QL, Wang B, Luo ZL, Tang LJ. Abdominal paracentesis drainage attenuates intestinal inflammation in severe acute pancreatitis rats through inhibiting the HMGB1-mediated TLR4 signaling pathway. World J Gastroenterol 2021; 27(9): 815-834
URL	https://www.wjgnet.com/1007-9327/full/v27/i9/815.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i9.815

Full Article (PDF)	WJG-27-815.pdf
Full Article (Word)	WJG-27-815.docx
Manuscript File	60344_Auto_Edited_LM-Webster J-Clear.docx
Answering Reviewers	60344-Answering reviewers.pdf
Audio Core Tip	60344-Audio core tip.m4a
Biostatistics Review Certificate	60344-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	60344-Conflict-of-interest statement.pdf
Copyright License Agreement	60344-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	60344-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	60344-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	60344-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	60344-Language certificate.pdf
Peer-review Report	60344-Peer-review(s).pdf
Scientific Misconduct Check	60344-Bing-Yan JP-1.png
Scientific Misconduct Check	60344-Bing-Fan JR-2.png
Scientific Misconduct Check	60344-Scientific misconduct check.pdf
Scientific Editor Work List	60344-Scientific editor work list.pdf