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2/20/2021 2:51:13 AM | Browse: 12 | Download: 24
Publication Name World Journal of Gastroenterology
Manuscript ID 60352
Country/Territory Saudi Arabia
Received
2020-10-26 20:17
Peer-Review Started
2020-10-26 20:18
To Make the First Decision
Return for Revision
2020-11-25 02:13
Revised
2020-11-30 09:24
Second Decision
2021-01-20 13:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-21 17:46
Articles in Press
2021-01-21 17:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-02-18 07:46
Publish the Manuscript Online
2021-02-20 02:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology and Pharmacy
Manuscript Type Basic Study
Article Title Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
Manuscript Source Unsolicited Manuscript
All Author List Mushtaq Ahmad Ansari, Mohammad Raish, Yousef A Bin Jardan, Ajaz Ahmad, Mudassar Shahid, Sheikh Fayaz Ahmad, Nazrul Haq, Mohammad Rashid Khan and Saleh A Bakheet
ORCID
Author(s) ORCID Number
Mushtaq Ahmad Ansari http://orcid.org/0000-0002-9106-0978
Mohammad Raish http://orcid.org/0000-0002-6015-6125
Yousef A Bin Jardan http://orcid.org/0000-0002-9106-0970
Ajaz Ahmad http://orcid.org/0000-0001-6295-8685
Mudassar Shahid http://orcid.org/0000-0003-3714-4772
Sheikh Fayaz Ahmad http://orcid.org/0000-0002-8282-3726
Nazrul Haq http://orcid.org/0000-0003-0666-808X
Mohammad Rashid Khan http://orcid.org/0000-0002-9106-09784
Saleh A Bakheet http://orcid.org/0000-0003-2322-9732
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research and Research Center at King Saud University RG-1439-083
Corresponding Author Mushtaq Ahmad Ansari, PhD, Associate Professor, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, King Khalid Road, Riyadh 11451, Saudi Arabia. muansari@ksu.edu.sa
Key Words Sinapic acid; D-galactosamine/lipopolysaccharide; Oxidative stress; Fulminant hepatitis; Antioxidant; Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
Core Tip This work demonstrated for the first time that the sinapic acid (SA) has hepatoprotective effects in the D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced rat model through its ability to suppress oxidative stress, inflammation, and apoptosis. The protective mechanism of SA depends on the downregulation of nuclear factor kappa-light-chain-enhancer of activated B cells and the restoration of antioxidant enzyme levels through the activation of the Nrf2/HO-1 pathway. Thus, SA could be applied to treat or prevent D-GalN/LPS -induced acute liver failure in the future.
Publish Date 2021-02-20 02:51
Citation Ansari MA, Raish M, Bin Jardan YA, Ahmad A, Shahid M, Ahmad SF, Haq N, Khan MR, Bakheet SA. Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways. World J Gastroenterol 2021; 27(7): 592-608
Url https://www.wjgnet.com/1007-9327/full/v27/i7/592.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i7.592
Full Article (PDF) WJG-27-592.pdf
Full Article (Word) WJG-27-592.docx
Manuscript File 60352_Auto_Edited_LM.docx
Answering Reviewers 60352-Answering reviewers.pdf
Audio Core Tip 60352-Audio core tip.m4a
Biostatistics Review Certificate 60352-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 60352-Conflict-of-interest statement.pdf
Copyright License Agreement 60352-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 60352-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 60352-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 60352-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 60352-Language certificate.pdf
Peer-review Report 60352-Peer-review(s).pdf
Scientific Misconduct Check 60352-Bing-Chen XF-1.png
Scientific Misconduct Check 60352-Scientific misconduct check.pdf
Scientific Editor Work List 60352-Scientific editor work list.pdf