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Articles Published Processes
9/5/2014 1:53:00 PM | Browse: 833 | Download: 840
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Received |
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2013-10-01 18:22 |
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Peer-Review Started |
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2013-10-01 20:15 |
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To Make the First Decision |
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2013-11-12 14:33 |
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Return for Revision |
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2013-11-12 19:14 |
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Revised |
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Second Decision |
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2014-04-17 14:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-04-17 15:05 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-04-27 11:20 |
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Typeset the Manuscript |
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2014-05-19 07:55 |
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Publish the Manuscript Online |
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2014-05-20 17:09 |
Category |
Immunology |
Manuscript Type |
Letter to the Editor |
Article Title |
Controversial issues regarding the roles of IL-10 and IFN-γ in active/inactive chronic hepatitis B
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Manuscript Source |
Invited Manuscript |
All Author List |
Hossein Khorramdelazad, Gholamhossein Hassanshahi and Mohammad Kazemi Arababadi |
Funding Agency and Grant Number |
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Corresponding Author |
Dr. Mohammad Kazemi Arababadi, Immunology of Infectious Disease Research Center, Rafsanjan University of Medical Sciences, Enghelab Square, Takhti Avenue, 7719617996 Rafsanjan, Iran. dr.kazemi@rums.ac.ir |
Key Words |
Hepatitis B virus; Interferon-γ; Interleukin-10 |
Core Tip |
Cytokines play a central role in the induction of appropriate immune responses against hepatitis B, as well as the clinical manifestations of the disease. Dimitropoulou et al showed that serum levels of interleukin 10 and interferon-γ decreased in patients with HBeAg-negative chronic active hepatitis B compared with inactive hepatitis B virus (HBV) carriers (Dimitropoulou et al, 2013) and concluded that this can lead to liver disease. However, we challenge their conclusion because we believe that inappropriate host immune responses are the main causes responsible for the clinical manifestations of the disease, but not the actual replication of the HBV particles. |
Publish Date |
2014-05-20 17:09 |
Citation |
Khorramdelazad H, Hassanshahi G, Arababadi MK. Controversial issues regarding the roles of IL-10 and IFN-γ in active/inactive chronic hepatitis B. World J Gastrointest Pathophysiol 2014; 5(2): 120-121 |
URL |
http://www.wjgnet.com/2150-5330/full/v5/i2/120.htm |
DOI |
http://dx.doi.org/10.4291/wjgp.v5.i2.120 |
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