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2/26/2021 5:58:37 AM | Browse: 643 | Download: 806
Publication Name World Journal of Gastroenterology
Manuscript ID 60749
Country/Territory United States
Received
2020-11-11 21:57
Peer-Review Started
2020-11-11 21:57
To Make the First Decision
Return for Revision
2020-12-17 23:05
Revised
2020-12-24 04:15
Second Decision
2021-01-21 13:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-21 18:32
Articles in Press
2021-01-21 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-01-25 19:23
Typeset the Manuscript
2021-02-08 03:15
Publish the Manuscript Online
2021-02-26 05:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment
Manuscript Source Unsolicited Manuscript
All Author List Ming Yang and Chun-Ye Zhang
ORCID
Author(s) ORCID Number
Ming Yang http://orcid.org/0000-0002-4895-5864
Chun-Ye Zhang http://orcid.org/0000-0003-2567-029X
Funding Agency and Grant Number
Corresponding Author Ming Yang, DVM, PhD, Postdoctoral Fellow, Department of Surgery, University of Missouri, One hospital Dr. Medical Science Building, Columbia, MO 65212, United States. yangmin@health.missouri.edu
Key Words Nonalcoholic fatty liver disease; G protein-coupled receptors; Metabolism; Bile acids; Short-chain fatty acids; Gut microbiota
Core Tip Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Without effective treatment, NAFLD can progress to fibrosis, cirrhosis, and final liver cancer. Currently, there is no efficacy treatment option, except the preventative strategies such as diet selection and excises. G protein-coupled receptors (GPCRs) have been shown to play essential roles in metabolic disorders, such as NAFLD and obesity, through their function as receptors for bile acids and free fatty acids. Therapies such as probiotics and GPCR agonists could be applied to modulate GPCR function to ameliorate liver metabolism syndrome. Herein, this review summarizes the current findings regarding the role of GPCRs in the development and progression of NAFLD and describes some preclinical and clinical studies of GPCR-mediated treatment.
Publish Date 2021-02-26 05:58
Citation Yang M, Zhang CY. G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment. World J Gastroenterol 2021; 27(8): 677-691
URL https://www.wjgnet.com/1007-9327/full/v27/i8/677.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i8.677
Full Article (PDF) WJG-27-677.pdf
Full Article (Word) WJG-27-677.docx
Manuscript File 60749-Review-FilipodiaCL.docx
Answering Reviewers 60749-Answering reviewers.pdf
Audio Core Tip 60749-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 60749-Conflict-of-interest statement.pdf
Copyright License Agreement 60749-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 60749-Grant application form(s).pdf
Peer-review Report 60749-Peer-review(s).pdf
Scientific Misconduct Check 60749-Scientific misconduct check.pdf
Scientific Editor Work List 60749-Scientific editor work list.pdf