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3/20/2021 2:13:53 AM | Browse: 339 | Download: 560
Publication Name World Journal of Hepatology
Manuscript ID 60878
Country/Territory United States
Received
2020-11-16 23:02
Peer-Review Started
2020-11-16 23:02
To Make the First Decision
Return for Revision
2021-01-18 01:16
Revised
2021-01-20 09:36
Second Decision
2021-03-08 07:04
Accepted by Journal Editor-in-Chief
2021-03-09 12:43
Accepted by Company Editor-in-Chief
2021-03-11 03:16
Articles in Press
2021-03-11 03:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-03-16 12:35
Publish the Manuscript Online
2021-03-20 02:13
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Hepatitis D virus and liver transplantation: Indications and outcomes
Manuscript Source Invited Manuscript
All Author List Haris Muhammad, Aniqa Tehreem, Muhammad Baraa Hammami, Peng-Sheng Ting, Ramzan Idilman and Ahmet Gurakar
ORCID
Author(s) ORCID Number
Haris Muhammad http://orcid.org/0000-0002-3472-6219
Aniqa Tehreem http://orcid.org/0000-0002-1007-9395
Muhammad Baraa Hammami http://orcid.org/0000-0002-6182-0227
Peng-Sheng Ting http://orcid.org/0000-0003-1581-2354
Ramzan Idilman http://orcid.org/0000-0001-8840-5472
Ahmet Gurakar http://orcid.org/0000-0002-2221-9148
Funding Agency and Grant Number
Corresponding Author Ahmet Gurakar, MD, Associate Professor, Director, Doctor, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Suite 918 , Baltimore, MA 21205, United States. aguraka1@jhmi.edu
Key Words Hepatitis delta virus; Liver transplant; Hepatitis B immunoglobins; Hepatocellular carcinoma
Core Tip Hepatitis D virus (HDV) is a dependent virus and relies on hepatitis B virus (HBV) to synthesize the pathogenic genomes. Therefore, it can only survive as a coinfection with HBV or as a superinfection. Chronic HDV infection results in rapid liver damage and can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Thus, liver transplant remains the only option for patients with end-stage liver disease, hepatocellular carcinoma due to coinfection or superinfection with HDV and HBV, fulminant liver failure and those who cannot be treated with interferon-based therapies. Post transplantation reinfection with HDV/HBV is an undesirable outcome. Though, there is a consensus that hepatitis B immune globulin in combination with a potent nucleoside/nucleotide analogue have shown promising results. In addition, there is ongoing research for newer treatment drugs. This review article focuses on liver transplant in patients as a result of hepatitis D virus. We have discussed the epidemiology, pathogenesis, clinical presentation, indication of liver transplantation, treatment options and the outcomes. New therapy trials have been also discussed in the treatment section. We believe that this topic is an area of knowledge gap and this article will cover the basics.
Publish Date 2021-03-20 02:13
Citation Muhammad H, Tehreem A, Hammami M, Ting PS, Idilman R, Gurakar A. Hepatitis D virus and liver transplantation: Indications and outcomes. World J Hepatol 2021; 13(3): 291-299
URL https://www.wjgnet.com/1948-5182/full/v13/i3/291.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i3.291
Full Article (PDF) WJH-13-291.pdf
Full Article (Word) WJH-13-291.docx
Manuscript File 60878_Auto_Edited.docx
Answering Reviewers 60878-Answering reviewers.pdf
Audio Core Tip 60878-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 60878-Conflict-of-interest statement.pdf
Copyright License Agreement 60878-Copyright license agreement.pdf
Peer-review Report 60878-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 60878-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 60878-Bing-Chen XF-1.png
Scientific Misconduct Check 60878-Scientific misconduct check.pdf
Scientific Editor Work List 60878-Scientific editor work list.pdf