Publication Name	World Journal of Stem Cells
Manuscript ID	60953
Country	Qatar

Received	2020-11-18 20:40
Peer-Review Started	2020-11-18 20:41
To Make the First Decision
Return for Revision	2021-01-25 18:47
Revised	2021-02-07 19:04
Second Decision	2021-03-10 07:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-11 03:15
Articles in Press	2021-03-11 03:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-03-24 06:13
Publish the Manuscript Online	2021-03-25 06:36

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Developmental Biology
Manuscript Type	Minireviews
Article Title	Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology
Manuscript Source	Invited Manuscript
All Author List	Ahmed K Elsayed, Selvaraj Vimalraj, Manjula Nandakumar and Essam M Abdelalim
ORCID	Author(s) ORCID Number Ahmed K Elsayed http://orcid.org/0000-0001-5887-9255 Selvaraj Vimalraj http://orcid.org/0000-0001-6951-4569 Manjula Nandakumar http://orcid.org/0000-0002-9732-9798 Essam M Abdelalim http://orcid.org/0000-0001-7764-6772
Funding Agency and Grant Number	Funding Agency Grant Number Qatar National Research Fund NPRP10-1221-160041
Corresponding Author	Essam M Abdelalim, DVM, MSc, PhD, Professor, Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Al Rayyan, Doha 34110, Qatar. emohamed@hbku.edu.qa
Key Words	Type 2 diabetes; Insulin target tissues; Human pluripotent stem cells; Induced pluripotent stem cells; Genetic factors; Disease modeling
Core Tip	The genetic factors involved in the development of insulin resistance (IR), associated with type 2 diabetes remains largely unknown due to the polygenic nature of IR and lack of the appropriate human model. In this review, we summarize and discuss the use of human pluripotent stem cell technology in studying the genetic defects underlying IR development as well as highlight the potential use of patient-derived pluripotent stem cell for in vitro IR modeling.
Publish Date	2021-03-25 06:36
Citation	Elsayed AK, Vimalraj S, Nandakumar M, Abdelalim EM. Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology. World J Stem Cells 2021; 13(3): 221-235
URL	https://www.wjgnet.com/1948-0210/full/v13/i3/221.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i3.221

Full Article (PDF)	WJSC-13-221.pdf
Full Article (Word)	WJSC-13-221.docx
Manuscript File	60953_Auto_Edited.docx
Answering Reviewers	60953-Answering reviewers.pdf
Audio Core Tip	60953-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	60953-Conflict-of-interest statement.pdf
Copyright License Agreement	60953-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	60953-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	60953-Language certificate.pdf
Peer-review Report	60953-Peer-review(s).pdf
Scientific Misconduct Check	60953-Bing-Yan JP-1.png
Scientific Misconduct Check	60953-Scientific misconduct check.pdf
Scientific Editor Work List	60953-Scientific editor work list.pdf