Publication Name	World Journal of Gastroenterology
Manuscript ID	6100
Country	South Korea

Received	2013-10-02 10:36
Peer-Review Started	2013-10-02 20:31
To Make the First Decision	2013-11-04 20:24
Return for Revision	2013-11-05 19:01
Revised	2013-11-27 01:25
Second Decision	2014-01-05 15:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-05 15:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-03 17:28
Typeset the Manuscript	2014-03-25 20:40
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Chemopreventive drugs: Mechanisms via inhibition of cancer stem cells in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Tae Il Kim
Funding Agency and Grant Number
Corresponding Author	Tae Il Kim, MD, PhD, Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun-gu, Seoul 120-752, South Korea. taeilkim@yuhs.ac
Key Words	Colorectal cancer; Chemoprevention; Cancer stem cell; Carcinogenesis; Microenvironment
Core Tip	To develop optimal chemopreventive agents, we need to target cells and pathways that are essential and critical to carcinogenesis: early tumorigenic changes of stem cells and signals for dedifferentiation may be good targets for chemoprevention. Major chemopreventive drugs, such as non-steroidal anti-inflammatory drugs, statins, proliferator-activated receptor γ agonists and metformin, have cancer stem cell (CSC)-suppressing effects via regulation of stem cell-regulating pathways, stem cell niche in the tumor microenvironment, and altered tumor metabolism. These stem cell-related steps in tumorigenesis could be critical targets for chemoprevention and CSC-targeted adjunctive treatment of colorectal cancer.
Publish Date	2014-04-14 10:49
Citation	Kim TI. Chemopreventive drugs: Mechanisms via inhibition of cancer stem cells in colorectal cancer. World J Gastroenterol 2014; 20(14): 3835-3846
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3835.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3835

Full Article (PDF)	WJG-20-3835.pdf
Full Article (Word)	WJG-20-3835.doc
Manuscript File	6100-Review.docx
Answering Reviewers	6100-Answering Reviewers.pdf
Copyright License Agreement	6100-Copyright assignment.pdf
Peer-review Report	6100-Peer review(s).pdf
Scientific Editor Work List	6100-Scientific editor work list.doc