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3/11/2021 8:31:02 AM | Browse: 335 | Download: 792
Publication Name World Journal of Gastroenterology
Manuscript ID 61152
Country/Territory New Zealand
Received
2020-11-26 05:22
Peer-Review Started
2020-11-26 05:22
To Make the First Decision
Return for Revision
2020-12-21 05:59
Revised
2021-01-03 08:53
Second Decision
2021-01-30 14:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-01 21:57
Articles in Press
2021-02-01 21:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-02-04 12:54
Typeset the Manuscript
2021-03-09 08:10
Publish the Manuscript Online
2021-03-11 08:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing CCNB1 expression
Manuscript Source Unsolicited Manuscript
All Author List Min Li, Hua Shang, Tao Wang, Shui-Qing Yang and Lei Li
ORCID
Author(s) ORCID Number
Min Li http://orcid.org/0000-0001-5062-3539
Hua Shang http://orcid.org/0000-0002-1899-9575
Tao Wang http://orcid.org/0000-0001-5062-3548
Shui-Qing Yang http://orcid.org/0000-0003-1923-7967
Lei Li http://orcid.org/0000-0001-5062-3538
Funding Agency and Grant Number
Corresponding Author Lei Li, PhD, Academic Research, Department of Pathology, University of Otago, 270 Great King Street , Dunedin px806, New Zealand. wshililei@buaa.edu.cn
Key Words Huanglian decoction (Coptidis Rhizoma, Zingiberis Rhizoma, Folium Artemisiae Argyi, Mume Fructus); Hepatocellular carcinoma; The Cancer Genome Atlas; Gene Expression Omnibus; P53 pathway; Cell cycle; Apoptosis
Core Tip The purpose of this study was to investigate the role and mechanism of Huanglian decoction on Hepatocellular carcinoma (HCC) cells. The results showed that Huanglian decoction has a significant inhibitory effect on the growth of HCC cells. Huanglian decoction can inhibit HCC cell growth by downregulating the expression of CCNB1 to activate the p53 signaling pathway. CCNB1 is a potential therapeutic target for liver cancer.
Publish Date 2021-03-11 08:31
Citation Li M, Shang H, Wang T, Yang SQ, Li L. Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing CCNB1 expression. World J Gastroenterol 2021; 27(10): 939-958
URL https://www.wjgnet.com/1007-9327/full/v27/i10/939.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i10.939
Full Article (PDF) WJG-27-939.pdf
Full Article (Word) WJG-27-939.docx
Manuscript File 61152_Auto_Edited_LM-Webster J-Clear.docx
Answering Reviewers 61152-Answering reviewers.pdf
Audio Core Tip 61152-Audio core tip.m4a
Biostatistics Review Certificate 61152-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61152-Conflict-of-interest statement.pdf
Copyright License Agreement 61152-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 61152-Language certificate.pdf
Supplementary Material 61152-Supplementary material.pdf
Peer-review Report 61152-Peer-review(s).pdf
Scientific Misconduct Check 61152-Bing-Huang P-1.png
Scientific Misconduct Check 61152-Bing-Fan JR-2.png
Scientific Misconduct Check 61152-Scientific misconduct check.pdf
Scientific Editor Work List 61152-Scientific editor work list.pdf