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4/9/2021 5:27:04 AM | Browse: 471 | Download: 1015
Publication Name World Journal of Diabetes
Manuscript ID 61279
Country/Territory China
Received
2020-12-08 11:19
Peer-Review Started
2020-12-08 11:20
To Make the First Decision
Return for Revision
2021-01-11 02:04
Revised
2021-01-25 18:51
Second Decision
2021-02-26 13:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-08 18:37
Articles in Press
2021-03-08 18:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-03-18 09:06
Typeset the Manuscript
2021-04-08 01:32
Publish the Manuscript Online
2021-04-09 05:27
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pathology
Manuscript Type Basic Study
Article Title Vascular endothelial growth factor B inhibits insulin secretion in MIN6 cells and reduces Ca2+ and cyclic adenosine monophosphate levels through PI3K/AKT pathway
Manuscript Source Unsolicited Manuscript
All Author List Jing-Dan Jia, Wen-Guo Jiang, Xu Luo, Rong-Rong Li, Yu-Chi Zhao, Geng Tian and Ya-Na Li
ORCID
Author(s) ORCID Number
Jing-Dan Jia http://orcid.org/0000-0003-2247-4541
Wen-Guo Jiang http://orcid.org/0000-0002-2561-9024
Xu Luo http://orcid.org/0000-0002-9163-0782
Rong-Rong Li http://orcid.org/0000-0002-5574-8425
Yu-Chi Zhao http://orcid.org/0000-0002-4776-1419
Geng Tian http://orcid.org/0000-0001-5877-5560
Ya-Na Li http://orcid.org/0000-0002-6441-5024
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 31771284
National Natural Science Foundation of China Youth Project 31702024
Major Basic Research Project of Shandong Provincial Natural Science Foundation ZR2019ZD27
Shandong Province Higher Educational Science and Technology Plan Project J17KA258
Corresponding Author Ya-Na Li, PhD, Associate Professor, Department of Pathophysiology, School of Basic Medicine, Binzhou Medical University, No. 346 Guanhai Road, Laishan District, Yantai 264003, Shandong Province, China. yaya-698@163.com
Key Words Type 2 diabetes; Insulin secretion; MIN6 cells; Vascular endothelial growth factor B; Blood glucose regulation
Core Tip Type 2 diabetes has elicited worldwide public health concerns, and mechanism regulating insulin secretion is unclear. We found that vascular endothelial growth factor B (VEGF-B) prevents MIN6 cells from secreting insulin through the PI3K-AKT (phosphatidylinositol 3-kinase-serine/threonine kinase) pathway. We have provided mechanistic insights into the effect of VEGF-B on insulin secretion and suggest VEGF-B as a new target that affects the occurrence and development of type 2 diabetes.
Publish Date 2021-04-09 05:27
Citation Jia JD, Jiang WG, Luo X, Li RR, Zhao YC, Tian G, Li YN. Vascular endothelial growth factor B inhibits insulin secretion in MIN6 cells and reduces Ca2+ and cyclic adenosine monophosphate levels through PI3K/AKT pathway. World J Diabetes 2021; 12(4): 480-498
URL https://www.wjgnet.com/1948-9358/full/v12/i4/480.htm
DOI https://dx.doi.org/10.4239/wjd.v12.i4.480
Full Article (PDF) WJD-12-480.pdf
Full Article (Word) WJD-12-480.docx
The ARRIVE Guidelines 61279-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 61279_Auto_Edited_LM_WangTQ.docx
Answering Reviewers 61279-Answering reviewers.pdf
Audio Core Tip 61279-Audio core tip.mp3
Biostatistics Review Certificate 61279-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61279-Conflict-of-interest statement.pdf
Copyright License Agreement 61279-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 61279-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 61279-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 61279-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 61279-Language certificate.pdf
Supplementary Material 61279-Supplementary material.pdf
Peer-review Report 61279-Peer-review(s).pdf
Scientific Misconduct Check 61279-Scientific misconduct check.pdf
Scientific Editor Work List 61279-Scientific editor work list.pdf