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4/9/2021 8:11:25 AM | Browse: 574 | Download: 803
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 61387
Country/Territory Japan
Received
2020-12-28 01:36
Peer-Review Started
2020-12-28 01:52
To Make the First Decision
Return for Revision
2021-01-17 22:51
Revised
2021-01-28 11:24
Second Decision
2021-03-03 03:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-11 03:03
Articles in Press
2021-03-11 03:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-03-22 01:20
Publish the Manuscript Online
2021-04-09 08:11
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Observational Study
Article Title Clinical efficacy and safety of second line and salvage aflibercept for advanced colorectal cancer in Akita prefecture
Manuscript Source Invited Manuscript
All Author List Taichi Yoshida, Kentaro Takahashi, Kengo Shibuya, Osamu Muto, Yuko Yoshida, Daiki Taguchi, Kazuhiro Shimazu, Koji Fukuda, Fuminori Ono, Kyoko Nomura and Hiroyuki Shibata
ORCID
Author(s) ORCID Number
Taichi Yoshida http://orcid.org/0000-0002-6912-3223
Kentaro Takahashi http://orcid.org/0000-0003-0419-7528
Kengo Shibuya http://orcid.org/0000-0002-4730-0022
Osamu Muto http://orcid.org/0000-0003-3965-1962
Yuko Yoshida http://orcid.org/0000-0003-2937-3903
Daiki Taguchi http://orcid.org/0000-0003-3426-8251
Kazuhiro Shimazu http://orcid.org/0000-0001-7725-9107
Koji Fukuda http://orcid.org/0000-0001-6101-6282
Fuminori Ono http://orcid.org/0000-0003-4169-8655
Kyoko Nomura http://orcid.org/0000-0003-1453-4540
Hiroyuki Shibata http://orcid.org/0000-0003-3581-3506
Funding Agency and Grant Number
Corresponding Author Hiroyuki Shibata, MD, PhD, Professor, Department of Clinical Oncology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan. hiroyuki@med.akita-u.ac.jp
Key Words Colorectal cancer; Aflibercept; Second-line chemotherapy; Folinic acid-fluorouracil-irinotecan; Palliative chemotherapy; Observational cohort study
Core Tip We compared the efficacy and safety of aflibercept plus the folinic acid-fluorouracil-irinotecan regimen as salvage treatment with those of second-line treatment in patients with advanced colorectal cancer. In the second-line and salvage therapy settings, the objective response rates were 11% and 0%, respectively (P = 0.50). The disease control rates, times to aflibercept treatment failure, median survival times post-aflibercept, and incidences of adverse effects greater than or equal to grade 3 were similar in the two groups. Aflibercept could be safe and confer a survival benefit in patients with advanced colorectal cancer, regardless of the number of treatment lines.
Publish Date 2021-04-09 08:11
Citation Yoshida T, Takahashi K, Shibuya K, Muto O, Yoshida Y, Taguchi D, Shimazu K, Fukuda K, Ono F, Nomura K, Shibata H. Clinical efficacy and safety of second line and salvage aflibercept for advanced colorectal cancer in Akita prefecture. World J Gastrointest Oncol 2021; 13(4): 295-304
URL https://www.wjgnet.com/1948-5204/full/v13/i4/295.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i4.295
Full Article (PDF) WJGO-13-295.pdf
Full Article (Word) WJGO-13-295.docx
STROBE Statement 61387-STROBE-Statement-revision.pdf
Manuscript File 61387_Auto_Edited.docx
Answering Reviewers 61387-Answering reviewers.pdf
Audio Core Tip 61387-Audio core tip.m4a
Biostatistics Review Certificate 61387-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61387-Conflict-of-interest statement.pdf
Copyright License Agreement 61387-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 61387-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 61387-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 61387-Language certificate.pdf
Peer-review Report 61387-Peer-review(s).pdf
Scientific Misconduct Check 61387-Bing-Ma YJ-1.jpg
Scientific Misconduct Check 61387-Bing-Fan JR-2.png
Scientific Misconduct Check 61387-Scientific misconduct check.pdf
Scientific Editor Work List 61387-Scientific editor work list.pdf