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9/11/2014 8:39:00 PM | Browse: 908 | Download: 791
Publication Name World Journal of Gastroenterology
Manuscript ID 6151
Country/Territory South Korea
Received
2013-10-06 17:36
Peer-Review Started
2013-10-07 12:32
To Make the First Decision
2013-11-04 20:16
Return for Revision
2013-11-05 19:46
Revised
2013-11-10 21:11
Second Decision
2013-11-29 10:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-30 01:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-12-13 15:51
Publish the Manuscript Online
2014-01-20 16:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Topic Highlights
Article Title Prospects for nucleic acid-based therapeutics against hepatitis C virus
Manuscript Source Invited Manuscript
All Author List Chang Ho Lee, Ji Hyun Kim and Seong-Wook Lee
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning 2012M3A9B6055200
National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning 2013R1A2A2A01004649
Corresponding Author Seong-Wook Lee, PhD, Professor, Department of Molecular Biology, Institute of Nanosensor and Biotechnology, Dankook University, 126, Jukjeon-dong, Suji-gu, Yongin 448-701, South Korea. swl0208@dankook.ac.kr
Key Words Hepatitis C virus; Nucleic acid-based therapeutics; Ribozyme; Aptamer; siRNA; Antisense oligonucleotide
Core Tip Nucleic acids have emerged as new anti-hepatitis C virus (HCV) agents due to their great specificity, chemical synthesizability, pharmaceutical amenability, and broad targeting ability. Clinical applications of nucleic acids have been delayed due to their potential immunogenicity and toxicity, low efficacy, possible off-target effects, and lack of efficient delivery vehicles. However, recent advances in delivery carriers and chemical modification methods have improved the efficacy and bioavailability of nucleic acid-based agents. Hence, nucleic acids may be attractive anti-HCV options. In this report, the current status and future prospects of ribozymes, aptamers, siRNAs, and antisense oligonucleotides as anti-HCV regimens will be discussed.
Publish Date 2014-01-20 16:41
Citation Lee CH, Kim JH, Lee SW. Prospects for nucleic acid-based therapeutics against hepatitis C virus. World J Gastroenterol 2013; 19(47): 8949-8962
URL http://www.wjgnet.com/1007-9327/full/v19/i47/8949.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i47.8949
Full Article (PDF) WJG-19-8949.pdf
Manuscript File 6151-Review.doc
Answering Reviewers 6151-Answering reviewers.pdf
Copyright License Agreement 6151-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 6151-Language certificate.pdf
Peer-review Report 6151-Peer review(s).pdf
Scientific Editor Work List 6151-Scientific editor work list.doc