| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Observational Study |
| Article Title |
Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
José Carlos Rodrigues Nascimento, Lianna C Pereira, Juliana Magalhães C Rêgo, Ronaldo P Dias, Paulo Goberlânio B Silva, Silvio Alencar C Sobrinho, Gustavo R Coelho, Ivelise Regina C Brasil, Edmilson F Oliveira-Filho, James S Owen, Pierluigi Toniutto and Reinaldo B Oriá |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Council for Scientific and Technological Development |
CNPq |
| Coordination for the Improvement of Higher Education Personnel |
CAPES |
| Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico |
FUNCAP |
|
| Corresponding Author |
Reinaldo B Oriá, DVM, PhD, Associate Professor, Research Scientist, Laboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine., Federal University of Ceara, Nunes de Melo, 1315–Rodolfo Teófilo, Fortaleza 60430-270, CE, Brazil. oria@ufc.br |
| Key Words |
Apolipoprotein E; Polymorphism; Liver cirrhosis; Hepatitis C virus; Hepatocellular carcinoma; Liver transplantation |
| Core Tip |
Hepatitis C virus (HCV) infection is responsible for a chronic liver inflammation, which may cause end-stage liver disease. Apolipoprotein E (protein: ApoE, gene: APOE) is key for lipid metabolism. In this study, the APOE4 allele, which has been associated with increased risk of acquiring late-onset Alzheimer’s disease, was found to have a protective effect against the progression of inflammation and/or fibrosis in liver damage induced by HCV pre- and post-liver transplantation. Further studies are needed to unravel the possible contribution of ApoE from the donor liver to this protection. |
| Publish Date |
2021-03-17 06:19 |
| Citation |
Nascimento JCR, Pereira LC, Rêgo JMC, Dias RP, Silva PGB, Sobrinho SAC, Coelho GR, Brasil IRC, Oliveira-Filho EF, Owen JS, Toniutto P, Oriá RB. Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis. World J Gastroenterol 2021; 27(11): 1064-1075 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i11/1064.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i11.1064 |
