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10/13/2021 12:57:54 PM | Browse: 12 | Download: 40
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 61745
Country/Territory China
2021-01-28 03:15
Peer-Review Started
2021-01-28 03:34
To Make the First Decision
Return for Revision
2021-06-04 00:42
2021-06-16 17:12
Second Decision
2021-07-14 03:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-14 09:24
Articles in Press
2021-07-14 09:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-07-26 01:29
Typeset the Manuscript
2021-10-09 10:46
Publish the Manuscript Online
2021-10-13 12:57
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells
Manuscript Source Unsolicited Manuscript
All Author List Guo-Jun Cao, Di Wang, Zhao-Pei Zeng, Guo-Xiang Wang, Chun-Jiu Hu and Zhi-Fang Xing
Author(s) ORCID Number
Guo-Jun Cao http://orcid.org/0000-0001-8925-9163
Di Wang http://orcid.org/0000-0002-0565-2484
Zhao-Pei Zeng http://orcid.org/0000-0003-0325-931X
Guo-Xiang Wang http://orcid.org/0000-0001-5367-7654
Chun-Jiu Hu http://orcid.org/0000-0002-4981-6524
Zhi-Fang Xing http://orcid.org/0000-0001-6507-8253
Funding Agency and Grant Number
Funding Agency Grant Number
Shanghai Health and Family Planning Commission 20154Y0141
Shanghai Development Program and the Project of Huashan Hospital North, Fudan University HSBY2019020
Shanghai "Rising Stars of Medical Talent" Youth Development Program
Corresponding Author Zhi-Fang Xing, PhD, Professor, Staff Physician, Department of Laboratory Medicine, Huashan Hospital North, Shanghai Medical College, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China. xzfisme@163.com
Key Words Rab4a; Rab5a; Epidermal growth factor; Cell proliferation; Gastric cancer; HGC-27 cell lines
Core Tip Firstly, our data proved that Rab5a can directly interact with Rab4a. Secondly, our study provided evidence that increased level of Rab5a can promote the expression of Rab4a, but increased Rab4a expression does not significantly affect Rab5a level. Lastly, our study suggests that the interaction between Rab5a and Rab4a is important for enhanced epidermal growth factor receptor expression on the cell membrane surface, which facilitates epidermal growth factor-stimulated proliferation of gastric cancer cells.
Publish Date 2021-10-13 12:57
Citation Cao GJ, Wang D, Zeng ZP, Wang GX, Hu CJ, Xing ZF. Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells. World J Gastrointest Oncol 2021; 13(10): 1492-1505
URL https://www.wjgnet.com/1948-5204/full/v13/i10/1492.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i10.1492
Full Article (PDF) WJGO-13-1492.pdf
Full Article (Word) WJGO-13-1492.docx
Manuscript File 61745-Review-FilipodiaCL.docx
Answering Reviewers 61745-Answering reviewers.pdf
Audio Core Tip 61745-Audio core tip.m4a
Biostatistics Review Certificate 61745-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61745-Conflict-of-interest statement.pdf
Copyright License Agreement 61745-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 61745-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 61745-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 61745-Language certificate.pdf
Peer-review Report 61745-Peer-review(s).pdf
Scientific Misconduct Check 61745-Scientific misconduct check.pdf
Scientific Editor Work List 61745-Scientific editor work list.pdf