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3/18/2021 6:54:27 AM | Browse: 588 | Download: 787
Publication Name World Journal of Experimental Medicine
Manuscript ID 61885
Country/Territory Türkiye
Received
2020-12-24 14:02
Peer-Review Started
2020-12-24 14:04
To Make the First Decision
Return for Revision
2021-01-18 03:43
Revised
2021-02-19 13:25
Second Decision
2021-03-11 13:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-12 00:49
Articles in Press
2021-03-12 00:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-03-18 02:29
Publish the Manuscript Online
2021-03-18 06:54
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Retrospective Study
Article Title Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy
Manuscript Source Invited Manuscript
All Author List Serdar Kabataş, Erdinç Civelek, Necati Kaplan, Eyüp Can Savrunlu, Gülseli Berivan Sezen, Mourat Chasan, Halil Can, Ali Genç, Yener Akyuva, Osman Boyalı, Furkan Diren and Erdal Karaoz
ORCID
Author(s) ORCID Number
Serdar Kabataş http://orcid.org/0000-0003-2691-6861
Erdinç Civelek http://orcid.org/0000-0002-3988-4064
Necati Kaplan http://orcid.org/0000-0001-5672-0566
Eyüp Can Savrunlu http://orcid.org/0000-0001-9022-200X
Gülseli Berivan Sezen http://orcid.org/0000-0001-9129-5470
Mourat Chasan http://orcid.org/0000-0001-8896-6915
Halil Can http://orcid.org/0000-0002-5699-4089
Ali Genç http://orcid.org/0000-0002-1784-3771
Yener Akyuva http://orcid.org/0000-0001-8171-5929
Osman Boyalı http://orcid.org/0000-0002-2500-1718
Furkan Diren http://orcid.org/0000-0001-6169-9722
Erdal Karaoz http://orcid.org/0000-0002-9992-833X
Funding Agency and Grant Number
Corresponding Author Serdar Kabataş, MD, PhD, Chairman, Full Professor, Department of Neurosurgery, University of Health Sciences, Gaziosmanpaşa Training and Research Hospital, Karayolları Mahallesi, Osmanbey Caddesi 616, İstanbul 34255, Türkiye. kabatasserdar@gmail.com
Key Words Hypoxic-ischemic encephalopathy; Stem cell; Transplantation; Wharton's jelly
Core Tip Occurring due to the disruption of oxygen supply to the brain, hypoxic-ischemic encephalopathy is associated with substantial rates of morbidity and mortality. In addition to supportive therapy and symptomatic treatment, research on the treatment of hypoxic-ischemic encephalopathy has focused new therapautic strategies as stem cell therapy. This multi-center and open-label phase I study was performed to investigate the safety and preliminary efficacy of multiple triple-route Wharton’s Jelly-Derived Mesenchymal Stem Cells administrations. The patients included in this study also had improvement in modified ashworth scores, Functional Independence Measure scores over the course of a year, indicating long-term impact on brain functions.
Publish Date 2021-03-18 06:54
Citation Kabataş S, Civelek E, Kaplan N, Savrunlu EC, Sezen GB, Chasan M, Can H, Genç A, Akyuva Y, Boyalı O, Diren F, Karaoz E. Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy. World J Exp Med 2021; 11(2): 17-29
URL https://www.wjgnet.com/2220-315x/full/v11/i2/17.htm
DOI https://dx.doi.org/10.5493/wjem.v11.i2.17
Full Article (PDF) WJEM-11-17.pdf
Full Article (Word) WJEM-11-17.docx
Manuscript File 61885_Auto_Edited.docx
Answering Reviewers 61885-Answering reviewers.pdf
Audio Core Tip 61885-Audio core tip.mp3
Biostatistics Review Certificate 61885-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61885-Conflict-of-interest statement.pdf
Copyright License Agreement 61885-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 61885-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 61885-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 61885-Language certificate.pdf
Peer-review Report 61885-Peer-review(s).pdf
Scientific Misconduct Check 61885-Bing-Wang JL-1.jpg
Scientific Misconduct Check 61885-Scientific misconduct check.pdf
Scientific Editor Work List 61885-Scientific editor work list.pdf