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8/26/2014 2:46:00 PM | Browse: 951 | Download: 679
Publication Name World Journal of Gastroenterology
Manuscript ID 6218
Country/Territory United States
Received
2013-10-09 09:05
Peer-Review Started
2013-10-09 23:31
To Make the First Decision
2013-12-26 11:09
Return for Revision
2013-12-26 15:44
Revised
2014-01-04 22:07
Second Decision
2014-01-20 18:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-20 19:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-05-13 11:42
Publish the Manuscript Online
2014-06-21 13:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Pediatric fatty liver disease: Role of ethnicity and genetics
Manuscript Source Invited Manuscript
All Author List Pierluigi Marzuillo, Emanuele Miraglia del Giudice and Nicola Santoro
Funding Agency and Grant Number
Funding Agency Grant Number
American Heart Association 13SDG14640038
2012 Yale Center for Clinical Investigation cholar award to Santoro N
CTSA from the National Center for Advancing Translational Science UL1 RR024139
Corresponding Author Nicola Santoro, MD, PhD, Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, PO Box 208064, New Haven, CT 06520, United States. nicola.santoro@yale.edu
Key Words Non alcoholic fatty liver disease; Ethnicity; Patatin like phospholipase containing domain 3 gene; Obesity; Insulin resistance; Glucokinase regulatory protein; Apolipoprotein C3 gene; Farnesyl-diphosphate farnesyltransferase 1
Core Tip The prevalence of hepatic steatosis varies among different ethnic groups. Ethnicity with the greatest prevalence of non-alcoholic fatty liver disease (NAFLD) is the Hispanic one followed by Caucasian and then African-Americans. NAFLD exhibits tight links with insulin resistance and metabolic syndrome. Several gene variants have been so far identified by Genome Wide Association Studies or by a candidate gene approach as associated with fatty liver disease. The PNPLA3 rs738409 and the GCKR rs1260326 are the strongest variants associated with fatty liver in paediatrics.
Publish Date 2014-06-21 13:56
Citation Marzuillo P, Miraglia del Giudice E, Santoro N. Pediatric fatty liver disease: Role of ethnicity and genetics. World J Gastroenterol 2014; 20(23): 7347-7355
URL http://www.wjgnet.com/1007-9327/full/v20/i23/7347.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i23.7347
Full Article (PDF) WJG-20-7347.pdf
Full Article (Word) WJG-20-7347.doc
Manuscript File 6218-Review.doc
Answering Reviewers 6218-Answering reviewers.pdf
Copyright License Agreement 6218-Copyright assignment.pdf
Peer-review Report 6218-Peer review(s).pdf
Scientific Editor Work List 6218-Scientific editor work list.doc