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4/9/2021 5:27:04 AM | Browse: 353 | Download: 554
Publication Name World Journal of Diabetes
Manuscript ID 62427
Country Japan
Received
2021-01-09 09:07
Peer-Review Started
2021-01-09 09:08
To Make the First Decision
Return for Revision
2021-01-24 23:45
Revised
2021-01-30 06:24
Second Decision
2021-03-03 03:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-03-11 02:58
Articles in Press
2021-03-11 02:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-03-18 01:30
Publish the Manuscript Online
2021-04-09 05:27
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medical Laboratory Technology
Manuscript Type Therapeutic and Diagnostic Guidelines
Article Title Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes
Manuscript Source Invited Manuscript
All Author List Masaki Nagaya, Koki Hasegawa, Ayuko Uchikura, Kazuaki Nakano, Masahito Watanabe, Kazuhiro Umeyama, Hitomi Matsunari, Kenji Osafune, Eiji Kobayashi, Hiromitsu Nakauchi and Hiroshi Nagashima
ORCID
Author(s) ORCID Number
Masaki Nagaya http://orcid.org/0000-0003-0784-5009
Koki Hasegawa http://orcid.org/0000-0003-2145-3183
Ayuko Uchikura http://orcid.org/0000-0002-1535-3808
Kazuaki Nakano http://orcid.org/0000-0003-1306-6247
Masahito Watanabe http://orcid.org/0000-0002-2021-575X
Kazuhiro Umeyama http://orcid.org/0000-0002-5096-1702
Hitomi Matsunari http://orcid.org/0000-0003-3787-4943
Kenji Osafune http://orcid.org/0000-0001-7238-2763
Eiji Kobayashi http://orcid.org/0000-0001-8617-3778
Hiromitsu Nakauchi http://orcid.org/0000-0002-8122-2566
Hiroshi Nagashima http://orcid.org/0000-0001-9940-8783
Funding Agency and Grant Number
Corresponding Author Masaki Nagaya, MD, PhD, Professor, Meiji University International Institute for Bio-Resource Research, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Kanagawa, Japan. m2nagaya@gmail.com
Key Words Pancreatic islet; Diabetes mellitus; Pig; Transgenic; Genetically engineering; Transplantation; Xenotransplantation
Core Tip Safer and more effective therapeutics are urgently required for managing the diabetes epidemic. Mice have been used predominantly as preclinical models for basic research on diabetes, although murine models are not ideally suited for translating basic knowledge into clinical applications. This article discusses features that attest to the attractiveness of genetically modified porcine models of diabetes for testing novel treatment strategies using recent technical advances.
Publish Date 2021-04-09 05:27
Citation Nagaya M, Hasegawa K, Uchikura A, Nakano K, Watanabe M, Umeyama K, Matsunari H, Osafune K, Kobayashi E, Nakauchi H, Nagashima H. Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes. World J Diabetes 2021; 12(4): 306-330
URL https://www.wjgnet.com/1948-9358/full/v12/i4/306.htm
DOI https://dx.doi.org/10.4239/wjd.v12.i4.306
Full Article (PDF) WJD-12-306.pdf
Full Article (Word) WJD-12-306.docx
Manuscript File 62427_Auto_Edited.docx
Answering Reviewers 62427-Answering reviewers.pdf
Audio Core Tip 62427-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 62427-Conflict-of-interest statement.pdf
Copyright License Agreement 62427-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 62427-Language certificate.pdf
Peer-review Report 62427-Peer-review(s).pdf
Scientific Misconduct Check 62427-Bing-Wang JL-1.jpg
Scientific Misconduct Check 62427-Scientific misconduct check.pdf
Scientific Editor Work List 62427-Scientific editor work list.pdf