Publication Name	World Journal of Gastroenterology
Manuscript ID	6260
Country	United States

Received	2013-10-10 19:20
Peer-Review Started	2013-10-12 13:45
To Make the First Decision	2013-11-12 18:13
Return for Revision	2013-11-14 16:14
Revised	2013-12-03 04:05
Second Decision	2014-01-05 14:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-05 15:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-13 10:23
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Intestinal stem cells and the colorectal cancer microenvironment
Manuscript Source	Invited Manuscript
All Author List	Bryan A Ong, Kenneth J Vega and Courtney W Houchen
Funding Agency and Grant Number
Corresponding Author	Courtney W Houchen, MD, Department of Digestive Diseases, University of Oklahoma Health Sciences Center, 1100 N Lindsay Ave, Oklahoma City, OK 73104, United States. courtney-houchen@ouhsc.edu
Key Words	Colon cancer stem cells; DCLK1 protein; Stem cell niche; Cell dedifferentiation
Core Tip	Colorectal (CRC) cancer stem cells are a theorized but poorly characterized cell population believed to be crucial for tumor growth, spread, and tenacity. CRC stem cells share many similar characteristics of normal intestinal stem cells and are hypothesized to originate directly from them. It appears, however, that both the regulation of normal intestinal stem cells and the development of CRC are far more complex than previously imagined. Likely pivotal to the success of both are plasticity pathways able to reverse cellular fate, and stem cell niche signals, ultimately leading to self-replenishment and sometimes also unwanted dissemination.
Publish Date	2014-02-26 11:18
Citation	Ong BA, Vega KJ, Houchen CW. Intestinal stem cells and the colorectal cancer microenvironment. World J Gastroenterol 2014; 20(8): 1898-1909
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/1898.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.1898

Full Article (PDF)	WJG-20-1898.pdf
Full Article (Word)	WJG-20-1898.doc
Manuscript File	6260-Review.doc
Answering Reviewers	6260-Answering reviewers.pdf
Copyright License Agreement	6260-Copyright assignment.pdf
Peer-review Report	6260-Peer review(s).pdf
Scientific Editor Work List	6260-Scientific editor work list.doc