Publication Name	World Journal of Gastroenterology
Manuscript ID	6271
Country

Received	2013-10-11 16:54
Peer-Review Started	2013-10-12 15:49
To Make the First Decision	2014-03-13 19:00
Return for Revision	2014-03-20 08:49
Revised	2014-03-28 21:04
Second Decision	2014-05-29 20:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 20:59
Articles in Press	2014-05-29 21:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-14 00:44
Typeset the Manuscript	2014-09-04 17:09
Publish the Manuscript Online	2014-09-19 19:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Original Articles
Article Title	Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma
Manuscript Source
All Author List	Jia-Ding Mao, Pei Wu, Jian-Xiong Huang, Jian Wu and Guang Yang
Funding Agency and Grant Number
Corresponding Author	Pei Wu, Professor, Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan Medical College, 10 Weiliu Road, Wuhu 241001, Anhui Province, China. maojiading0205@sina.com
Key Words	Gastrin; Mitogen-activated protein kinase; Extracellular signal-regulated protein kinase 1/2; K-ras; Large intestinal carcinoma
Core Tip	We have demonstrated that large intestinal carcinoma is related to abnormal expression of gastrin. Gastrin promoted growth of large intestinal cancer cell via gastrin receptor, but the detailed molecular mechanism is not fully known. We elucidated the molecular mechanisms of gastrin-induced growth of large intestinal cancer in relation to the extracellular signal-regulated protein kinase-mitogen-activated protein kinase (ERK-MAPK) signaling pathway. We attempted to establish a new gastrin-ERK-MAPK pathway in gastrin-dependent large intestinal cancer; provide a new way to interfere with the signaling pathway of gastrin-induced growth of large intestinal cancer; and to offer a new target for gene therapy of large intestinal carcinoma.
Publish Date	2014-09-19 19:25
Citation	Mao JD, Wu P, Huang JX, Wu J, Yang G. Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma. World J Gastroenterol 2014; 20(35): 12542-12550
URL	http://www.wjgnet.com/1007-9327/full/v20/i35/12542.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i35.12542

Full Article (PDF)	WJG-20-12542.pdf
Full Article (Word)	WJG-20-12542.doc
Manuscript File	6271-Review.doc
Answering Reviewers	6271-Answering reviewers.pdf
Copyright License Agreement	6271-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6271-Language certificate.PDF
Scientific Misconduct Check	6271-CrossCheck.jpg
Scientific Editor Work List	6271-Scientific editor work list.pdf