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6/11/2021 9:22:17 AM | Browse: 205 | Download: 350
Publication Name World Journal of Clinical Cases
Manuscript ID 62796
Country/Territory China
Received
2021-01-26 14:56
Peer-Review Started
2021-01-26 14:58
To Make the First Decision
Return for Revision
2021-02-25 04:02
Revised
2021-03-11 05:46
Second Decision
2021-04-12 12:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-04-12 17:26
Articles in Press
2021-04-12 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-04-16 01:41
Typeset the Manuscript
2021-05-31 11:42
Publish the Manuscript Online
2021-06-11 09:22
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases
Manuscript Source Unsolicited Manuscript
All Author List Cai-Bao Jin and Ling Yang
ORCID
Author(s) ORCID Number
Cai-Bao Jin http://orcid.org/0000-0003-3544-5774
Ling Yang http://orcid.org/0000-0002-5914-9614
Funding Agency and Grant Number
Corresponding Author Ling Yang, MD, Chief Doctor, Department of Thoracic Oncology, Hubei Cancer Hospital, No. 116 Zhuodaoquan South Road, Wuhan 430000, Hubei Province, China. 348711624@qq.com
Key Words Histological transformation; Epidermal growth factor receptor tyrosine kinase inhibitors; Non-small cell lung cancer; Tumor re-biopsy; Epidermal growth factor receptor mutation
Core Tip We retrospectively diagnosed 9 cases of non-small cell lung cancer (SCLC) transforming to SCLC, large-cell neuroendocrine carcinoma or squamous cell carcinoma on re-biopsy after epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Tumor re-biopsy should be performed routinely when EGFR-TKI therapy fails in lung cancer patients to avoid ignoring histological transformation and to select a subsequent therapeutic strategy. The plasma pro-gastrin-releasing peptide and NSE levels could be valuable and significant biomarkers to predict histological transformation. The transformed tumor retained the original EGFR mutation, which indicates that histological transformation represents an evolution from the initial tumor.
Publish Date 2021-06-11 09:22
Citation Jin CB, Yang L. Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases. World J Clin Cases 2021; 9(18): 4617-4626
URL https://www.wjgnet.com/2307-8960/full/v9/i18/4617.htm
DOI https://dx.doi.org/10.12998/wjcc.v9.i18.4617
Full Article (PDF) WJCC-9-4617.pdf
Full Article (Word) WJCC-9-4617.docx
Manuscript File 62796_Auto_Edited_LM_WangTQ.docx
Answering Reviewers 62796-Answering reviewers.pdf
Audio Core Tip 62796-Audio core tip.m4a
Biostatistics Review Certificate 62796-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 62796-Conflict-of-interest statement.pdf
Copyright License Agreement 62796-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 62796-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 62796-Language certificate.pdf
Peer-review Report 62796-Peer-review(s).pdf
Scientific Misconduct Check 62796-Bing-Wang JL-1.jpg
Scientific Misconduct Check 62796-Bing-Fan JR-2.png
Scientific Misconduct Check 62796-Scientific misconduct check.pdf
Scientific Editor Work List 62796-Scientific editor work list.pdf