Publication Name	World Journal of Diabetes
Manuscript ID	62842
Country	United Kingdom

Received	2022-01-27 20:53
Peer-Review Started	2022-01-27 20:54
To Make the First Decision
Return for Revision	2022-04-18 00:23
Revised	2022-04-24 11:08
Second Decision	2022-05-23 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-28 07:03
Articles in Press	2022-05-28 07:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-05-31 07:36
Publish the Manuscript Online	2022-06-08 02:31

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders
Manuscript Source	Invited Manuscript
All Author List	Arjun Jain, Kristof Bozovicar, Vidhi Mehrotra, Tomaz Bratkovic, Martin H Johnson and Ira Jha
ORCID	Author(s) ORCID Number Arjun Jain http://orcid.org/0000-0003-0396-9290 Kristof Bozovicar http://orcid.org/0000-0003-0025-1734 Vidhi Mehrotra http://orcid.org/0000-0002-2037-4355 Tomaz Bratkovic http://orcid.org/0000-0001-8367-5465 Martin H Johnson http://orcid.org/0000-0002-5906-5883 Ira Jha http://orcid.org/0000-0002-1067-8208
Funding Agency and Grant Number
Corresponding Author	Arjun Jain, MPhil, PhD, Research Scientist, . jain_arjun@yahoo.com
Key Words	Endothelin-1; Endothelin-traps; Diabetes; Heart failure; Chronic kidney disease; Novel therapeutic
Core Tip	This study verified the specificity of endothelin (ET)-traps, which are an Fc-based fusion protein that acts as a potential therapeutic for various cET-1 related disorders, including diabetes and chronic kidney disease. ET-traps, unlike ET receptor antagonists, do not completely block the ET system and hence have minimal side effects. ET-traps would help save millions of lives around the world.
Publish Date	2022-06-08 02:31
Citation	Jain A, Bozovicar K, Mehrotra V, Bratkovic T, Johnson MH, Jha I. Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders. World J Diabetes 2022; 13(6): 434-441
URL	https://www.wjgnet.com/1948-9358/full/v13/i6/434.htm
DOI	https://dx.doi.org/10.4239/wjd.v13.i6.434

Full Article (PDF)	WJD-13-434.pdf
Full Article (Word)	WJD-13-434.docx
Manuscript File	62842_Auto_Edited-LS.docx
Answering Reviewers	62842-Answering reviewers.pdf
Audio Core Tip	62842-Audio core tip.m4a
Biostatistics Review Certificate	62842-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	62842-Conflict-of-interest statement.pdf
Copyright License Agreement	62842-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	62842-Institutional review board statement.pdf
Peer-review Report	62842-Peer-review(s).pdf
Scientific Editor Work List	62842-Scientific editor work list.pdf