Publication Name	World Journal of Gastroenterology
Manuscript ID	63287
Country	China

Received	2021-01-27 03:45
Peer-Review Started	2021-01-27 03:47
To Make the First Decision
Return for Revision	2021-05-02 02:34
Revised	2021-05-14 05:11
Second Decision	2021-08-03 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-03 07:05
Articles in Press	2021-08-03 07:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-16 09:43
Typeset the Manuscript	2021-09-02 03:47
Publish the Manuscript Online	2021-09-09 06:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Recent advances in blood-based and artificial intelligence-enhanced approaches for gastrointestinal cancer diagnosis
Manuscript Source	Invited Manuscript
All Author List	Li-Shi Li, Xiang-Yu Guo and Kun Sun
ORCID	Author(s) ORCID Number Li-Shi Li http://orcid.org/0000-0003-2117-7529 Xiang-Yu Guo http://orcid.org/0000-0001-5835-490X Kun Sun http://orcid.org/0000-0002-9883-1616
Funding Agency and Grant Number	Funding Agency Grant Number Guangdong Basic and Applied Basic Research Foundation 2019A1515110173 BGI-research BGIRSZ2020007 Shenzhen Bay Laboratory
Corresponding Author	Kun Sun, PhD, Assistant Professor, Institute of Cancer Research, Shenzhen Bay Laboratory, Rm B302, Guangming International Innovation Center, Guangming District, Shenzhen 518132, Guangdong Province, China. sunkun@szbl.ac.cn
Key Words	Liquid biopsy; Plasma cell-free DNA; Circulating tumor cell; Extracellular vesicle; Exosome; Artificial intelligence
Core Tip	Recent studies had discovered a variety of blood-based biomarkers with great potential in improving the diagnosis and surveillance of gastrointestinal (GI) cancers. In this article, we review the latest advances in diagnosis of various GI cancers, focusing on emerging blood-based liquid biopsy assays and artificial intelligence-enhanced approaches. We also discuss purity assessment approaches for tissue biopsies which is an important issue in cancer studies, especially those applicable in metastatic GI cancers.
Publish Date	2021-09-09 06:46
Citation	Li LS, Guo XY, Sun K. Recent advances in blood-based and artificial intelligence-enhanced approaches for gastrointestinal cancer diagnosis. World J Gastroenterol 2021; 27(34): 5666-5681
URL	https://www.wjgnet.com/1007-9327/full/v27/i34/5666.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i34.5666

Full Article (PDF)	WJG-27-5666.pdf
Full Article (Word)	WJG-27-5666.docx
Manuscript File	63287_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers	63287-Answering reviewers.pdf
Audio Core Tip	63287-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63287-Conflict-of-interest statement.pdf
Copyright License Agreement	63287-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63287-Grant application form(s).pdf
Peer-review Report	63287-Peer-review(s).pdf
Scientific Misconduct Check	63287-Scientific misconduct check.pdf
Scientific Editor Work List	63287-Scientific editor work list.pdf