| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nikolett Bódi, Diána Mezei, Payal Chakraborty, Zita Szalai, Bence Pál Barta, János Balázs, Zsolt Rázga, Edit Hermesz and Mária Bagyánszki |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| European Union and the Hungarian Government in the framework |
EFOP-3.6.1-16-2016-00008 |
| Hungarian NKFIH |
FK131789 (N.B.) |
| János Bolyai Research Scholarship of the Hungarian Academy of Sciences (N.B.) |
|
| New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund |
ÚNKP-20-5 (B.N.) |
|
| Corresponding Author |
Mária Bagyánszki, PhD, Associate Professor, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged 6726, Hungary. bmarcsi@bio.u-szeged.hu |
| Key Words |
Type 1 diabetes; Diabetic enteric neuropathy; Neuronal microenvironment; Basement membrane; Matrix metalloproteinase 9; Tissue inhibitor of metalloproteinase 1 |
| Core Tip |
These findings demonstrate an intestinal segment-specific thickening of basement membrane (BM) surrounding myenteric ganglia. In diabetes, ganglionic BM is thickened in the ileum, but not in the duodenum. Insulin prevented the diabetes-related BM thickening. The matrix degrading matrix metalloproteinase 9 (MMP9) expression was decreased in myenteric ganglia and its environment in the diabetic ileum, however, it remained unchanged in the duodenum. Similarly, MMP9/Tissue inhibitor of metalloproteinase 1 (TIMP1) ratio decreased only in ileal myenteric ganglia. Intestinal segment-specific induction of MMP9 and TIMP1 messenger ribonucleic acid levels was revealed. Regionally decreased MMP9 expression in ganglia correlates well with segment-specific thickening of ganglionic BM and these coincide with region-dependent enteric neuronal damage. |
| Publish Date |
2021-05-06 11:18 |
| Citation |
Bódi N, Mezei D, Chakraborty P, Szalai Z, Barta BP, Balázs J, Rázga Z, Hermesz E, Bagyánszki M. Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia. World J Diabetes 2021; 12(5): 658-672 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i5/658.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i5.658 |
