Publication Name	World Journal of Gastroenterology
Manuscript ID	63328
Country	Italy

Received	2021-01-27 10:47
Peer-Review Started	2021-01-27 10:50
To Make the First Decision
Return for Revision	2021-02-25 06:22
Revised	2021-03-04 21:29
Second Decision	2021-04-07 12:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-07 19:05
Articles in Press	2021-04-07 19:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-16 03:38
Typeset the Manuscript	2021-04-30 03:13
Publish the Manuscript Online	2021-05-20 08:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Breakthroughs and challenges in the management of pediatric viral hepatitis
Manuscript Source	Invited Manuscript
All Author List	Emanuele Nicastro, Lorenzo Norsa, Angelo Di Giorgio, Giuseppe Indolfi and Lorenzo D'Antiga
ORCID	Author(s) ORCID Number Emanuele Nicastro http://orcid.org/0000-0002-4518-9375 Lorenzo Norsa http://orcid.org/0000-0003-3322-2921 Angelo Di Giorgio http://orcid.org/0000-0003-0363-5565 Giuseppe Indolfi http://orcid.org/0000-0003-3830-9823 Lorenzo D'Antiga http://orcid.org/0000-0001-7150-3148
Funding Agency and Grant Number
Corresponding Author	Emanuele Nicastro, MD, PhD, N/A, Department of Pediatric Gastroenterology Hepatology and Transplantation, ASST Papa Giovanni XXIII, Piazza OMS 1, Bergamo 24127, Italy. enicastro@asst-pg23.it
Key Words	Hepatitis C; Hepatitis B; Direct acting antivirals; Liver cirrhosis; Children
Core Tip	Chronic hepatitis B and C account for substantial morbidity and mortality worldwide. Infection control in children has great clinical and epidemiological implications. This review aims to discuss recent achievements and forthcoming opportunities in the management of pediatric viral hepatitis. Removing barriers to the access to novel direct acting antivirals, and understanding the relevance of tolerance-breaking new approaches to infection control, are major challenges for the pediatric hepatologists.
Publish Date	2021-05-20 08:38
Citation	Nicastro E, Norsa L, Di Giorgio A, Indolfi G, D'Antiga L. Breakthroughs and challenges in the management of pediatric viral hepatitis. World J Gastroenterol 2021; 27(20): 2474-2494
URL	https://www.wjgnet.com/1007-9327/full/v27/i20/2474.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i20.2474

Full Article (PDF)	WJG-27-2474.pdf
Full Article (Word)	WJG-27-2474.docx
Manuscript File	63328-Review-FilipodiaCL.docx
Answering Reviewers	63328-Answering reviewers.pdf
Audio Core Tip	63328-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63328-Conflict-of-interest statement.pdf
Copyright License Agreement	63328-Copyright license agreement.pdf
Peer-review Report	63328-Peer-review(s).pdf
Scientific Misconduct Check	63328-Scientific misconduct check.pdf
Scientific Editor Work List	63328-Scientific editor work list.pdf