| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiu-Yan Li, Qing-Xia Guan, Yu-Zhou Shang, Yan-Hong Wang, Shao-Wa Lv, Zhi-Xin Yang, Rui Wang, Yu-Fei Feng, Wei-Nan Li and Yong-Ji Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82074025 |
| National Natural Science Foundation of China |
82074271 |
| the Heilongjiang Traditional Chinese Medicine Research Project |
ZHY18-047 |
| Scientific Research Project of Heilongjiang Health Committee |
2020-293 |
|
| Corresponding Author |
Yong-Ji Li, PhD, Professor, College of Pharmacy, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin 150040, Heilongjiang Province, China. liyongji2009@163.com |
| Key Words |
Norcantharidin; Metal-organic frameworks; IRMOF-3; Temperature-sensitive gel; Drug delivery; Liver cancer |
| Core Tip |
Norcantharidin (NCTD) is suitable for the treatment of primary liver cancer, especially early and middle primary liver cancer. However, the side effects of NCTD have limited its application. Therefore, we aimed to establish a liver-targeting therapy in which NCTD is loaded into IRMOF-3 coated with a thermosensitive gel, which can be efficiently delivered to liver cancer cells and slowly released. The results reveal that this thermosensitive gel-encapsulated IRMOF-3 has great advantages as an antitumor drug carrier and provides some ideas for passive targeting therapy of tumors. |
| Publish Date |
2021-07-12 00:42 |
| Citation |
Li XY, Guan QX, Shang YZ, Wang YH, Lv SW, Yang ZX, Wang R, Feng YF, Li WN, Li YJ. Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer. World J Gastroenterol 2021; 27(26): 4208-4220 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i26/4208.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i26.4208 |
