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10/13/2021 8:37:10 AM | Browse: 203 | Download: 230
Publication Name World Journal of Diabetes
Manuscript ID 63436
Country/Territory India
Received
2021-01-28 10:37
Peer-Review Started
2021-01-28 10:40
To Make the First Decision
Return for Revision
2021-05-03 21:55
Revised
2021-05-22 07:21
Second Decision
2021-07-05 05:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-05 09:35
Articles in Press
2021-07-05 09:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-09-04 05:19
Typeset the Manuscript
2021-09-30 12:11
Publish the Manuscript Online
2021-10-13 08:37
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Review
Article Title Role of nucleic acid sensing in the pathogenesis of type-1 diabetes
Manuscript Source Invited Manuscript
All Author List Darshan Badal, Naresh Sachdeva, Deep Maheshwari and Preetam Basak
ORCID
Author(s) ORCID Number
Darshan Badal http://orcid.org/0000-0001-7582-6366
Naresh Sachdeva http://orcid.org/0000-0001-6289-4749
Deep Maheshwari http://orcid.org/0000-0003-4512-7948
Preetam Basak http://orcid.org/0000-0003-3792-7929
Funding Agency and Grant Number
Funding Agency Grant Number
Council of Scientific and Industrial Research, Government of India 27 (0328)/17/EMR-II (awarded to Sachdeva N)
Corresponding Author Naresh Sachdeva, MSc, PhD, Additional Professor, Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. naresh_pgi@hotmail.com
Key Words Nucleic acid sensing; Type-1 diabetes; Pattern recognition receptors; Nucleic acid receptors; Type-1 interferon; Beta cells
Core Tip Under abnormal physiological conditions such as excessive cellular stress or apoptosis, endogenous self-nucleic acids like DNA, RNA or mitochondrial DNA accumulate in extranuclear compartments or extracellular spaces or form complexes with host proteins. Such situations sometimes lead to the failure of discriminating mechanisms of nucleic acid sensors leading to proinflammatory responses as seen in autoimmune diseases like systemic lupus erythematosus, psoriasis and to some extent in type-1 diabetes (T1D). The understanding of the role of nucleic acid-sensing and their downstream signaling pathways is gradually evolving and provides another avenue in exploring therapeutic options for treating autoimmune diseases like T1D.
Publish Date 2021-10-13 08:37
Citation Badal D, Sachdeva N, Maheshwari D, Basak P. Role of nucleic acid sensing in the pathogenesis of type-1 diabetes. World J Diabetes 2021; 12(10): 1654-1673
URL https://www.wjgnet.com/1948-9358/full/v12/i10/1655.htm
DOI https://dx.doi.org/10.4239/wjd.v12.i10.1655
Full Article (PDF) WJD-12-1655.pdf
Full Article (Word) WJD-12-1655.docx
Manuscript File 63436-Review-Filipodia-CL.docx
Answering Reviewers 63436-Answering reviewers.pdf
Audio Core Tip 63436-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 63436-Conflict-of-interest statement.pdf
Copyright License Agreement 63436-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 63436-Grant application form(s).pdf
Peer-review Report 63436-Peer-review(s).pdf
Scientific Misconduct Check 63436-Scientific misconduct check.pdf
Scientific Editor Work List 63436-Scientific editor work list.pdf