Publication Name	World Journal of Gastroenterology
Manuscript ID	6373
Country	Italy

Received	2013-10-15 14:28
Peer-Review Started	2013-10-16 13:26
To Make the First Decision	2013-10-29 12:25
Return for Revision	2013-10-30 10:39
Revised
Second Decision	2014-01-02 10:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-02 12:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-20 09:56
Publish the Manuscript Online	2014-01-26 20:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives
Manuscript Source	Invited Manuscript
All Author List	Caterina Fanali, Donatella Lucchetti, Marisa Farina, Maddalena Corbi, Valerio Cufino, Achille Cittadini and Alessandro Sgambato
Funding Agency and Grant Number
Corresponding Author	Alessandro Sgambato, MD, PhD, Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy. asgambato@rm.unicatt.it
Key Words	Colorectal cancer; Cancer stem cells; Tumorigenesis; Cancer therapy; Prognostic marker
Core Tip	A better understanding of the mechanisms responsible for tumor initiation and progression is essential for the development of novel, more powerful therapies for colorectal cancer patients. In this paper, we review the basic concepts of both the traditional “stochastic”, and of the more recent, “hierarchical” models of tumor development. We then introduce the so-called cancer stem cells (CSCs) and provides an overview of the proposed roles of CSCs in human colorectal tumorigenesis focusing on the most important molecules identified as CSC-specific marker in colorectal cancer and on the potential strategies for the development of CSC-targeted therapy.
Publish Date	2014-01-26 20:08
Citation	Fanali C, Lucchetti D, Farina M, Corbi M, Cufino V, Cittadini A, Sgambato A. Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives. World J Gastroenterol 2014; 20(4): 923-942
URL	http://www.wjgnet.com/1007-9327/full/v20/i4/923.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i4.923

Full Article (PDF)	WJG-20-923.pdf
Full Article (Word)	WJG-20-923.doc
Manuscript File	6373-review.docx
Answering Reviewers	6373-Answering reviewers.pdf
Copyright License Agreement	6373-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6373-Language certificate.pdf
Peer-review Report	6373-Peer review(s).pdf
Scientific Editor Work List	6373-Scientific editor work list.doc