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Articles Published Processes
6/12/2021 10:20:44 PM | Browse: 535 | Download: 716
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Received |
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2021-02-01 16:41 |
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Peer-Review Started |
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2021-02-01 16:51 |
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To Make the First Decision |
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Return for Revision |
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2021-03-08 06:40 |
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Revised |
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2021-03-17 17:07 |
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Second Decision |
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2021-05-24 12:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-05-24 12:45 |
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Articles in Press |
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2021-05-24 12:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-06-04 08:00 |
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Publish the Manuscript Online |
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2021-06-12 22:20 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Liver transplantation in acute liver failure: Dilemmas and challenges
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ramesh Kumar, Utpal Anand and Rajeev Nayan Priyadarshi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ramesh Kumar, MD, Associate Professor, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, Bihar, India. docrameshkr@gmail.com |
| Key Words |
Acute liver failure; Fulminant hepatic failure; Prognosis; Kings college criteria; Liver transplantation; Acetaminophen |
| Core Tip |
Liver transplantation (LT) is a lifesaving procedure for patients with acute liver failure (ALF). Its use, however, is constrained by the absence of reliable prognostic models that hampers the selection of transplant candidates in a timely and precise manner. The survival of medically treated ALF patients has increased over time, but the criteria for LT remain the same. No clear advantage of LT in acetaminophen-associated ALF appears to be present. The other problems associated with LT in ALF are diagnostic dilemmas, shortage of graft, waiting list contraindications, vaguely defined delisting criteria, pre-transplant assessment time limits, ethical concerns, and comparatively poor post-transplant outcomes. Therefore, there is a desperate need to establish accurate prognostic models and explore the roles of alternative therapies to enhance transplant-free survival and fill the gap produced by the shortage of graft. |
| Publish Date |
2021-06-12 22:20 |
| Citation |
Kumar R, Anand U, Priyadarshi RN. Liver transplantation in acute liver failure: Dilemmas and challenges. World J Transplant 2021; 11(6): 187-202 |
| URL |
https://www.wjgnet.com/2220-3230/full/v11/i6/187.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v11.i6.187 |
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