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6/8/2021 10:51:03 AM | Browse: 14 | Download: 27
Publication Name World Journal of Gastroenterology
Manuscript ID 63873
Country/Territory Italy
Received
2021-02-09 16:17
Peer-Review Started
2021-02-04 15:23
To Make the First Decision
Return for Revision
2021-03-28 22:33
Revised
2021-04-09 07:16
Second Decision
2021-05-07 08:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-05-07 12:00
Articles in Press
2021-05-07 12:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-06-02 03:24
Publish the Manuscript Online
2021-06-08 10:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+ CD25+ Foxp3+ regulatory T cells in the immune microenvironment
Manuscript Source Invited Manuscript
All Author List Alessandro Granito, Luigi Muratori, Claudine Lalanne, Chiara Quarneti, Silvia Ferri, Marcello Guidi, Marco Lenzi and Paolo Muratori
ORCID
Author(s) ORCID Number
Alessandro Granito http://orcid.org/0000-0002-0637-739X
Luigi Muratori http://orcid.org/0000-0002-8748-8031
Claudine Lalanne http://orcid.org/0000-0002-8438-9060
Chiara Quarneti http://orcid.org/0000-0002-0637-731X
Silvia Ferri http://orcid.org/0000-0002-6033-8594
Marcello Guidi http://orcid.org/0000-0002-8857-0096
Marco Lenzi http://orcid.org/0000-0001-8558-0793
Paolo Muratori http://orcid.org/0000-0002-5899-5966
Funding Agency and Grant Number
Corresponding Author Alessandro Granito, MD, Assistant Professor, Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Via Albertoni 15, Bologna 40138, Italy. alessandro.granito@unibo.it
Key Words Autoimmune liver disease; Hepatitis B virus-related chronic hepatitis; Hepatitis C virus-related chronic hepatitis; Hepatocellular carcinoma; Tumor microenvironment
Core Tip Hepatocellular carcinoma (HCC) is the fifth most common cancer with poor prognosis despite significant improved diagnostic and therapeutic strategies. Most of HCC occurs in cirrhotic patients, with hepatitis B and C viruses being leading causes, Recent studies showed that HCC development and progression are associated with a unique immune response profile of the liver microenvironment where CD4+CD25+ Foxp3 regulatory T-cells (Tregs) play a crucial role through their immunosuppressive role. We discuss the role of Tregs in chronic liver diseases as well as in HCC initiation and the role of immunotherapy to enhance anti-tumor immune response by blocking Treg activity.
Publish Date 2021-06-08 10:51
Citation Granito A, Muratori L, Lalanne C, Quarneti C, Ferri S, Guidi M, Lenzi M, Muratori P. Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+ CD25+ Foxp3+ regulatory T cells in the immune microenvironment. World J Gastroenterol 2021; 27(22): 2994-3009
URL https://www.wjgnet.com/1007-9327/full/v27/i22/2994.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i22.2994
Full Article (PDF) WJG-27-2994.pdf
Full Article (Word) WJG-27-2994.docx
Manuscript File 63873_Auto_Edited-JPY.docx
Answering Reviewers 63873-Answering reviewers.pdf
Audio Core Tip 63873-Audio core tip.aac
Conflict-of-Interest Disclosure Form 63873-Conflict-of-interest statement.pdf
Copyright License Agreement 63873-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 63873-Language certificate.pdf
Peer-review Report 63873-Peer-review(s).pdf
Scientific Misconduct Check 63873-Bing-Wang JL-1.jpg
Scientific Misconduct Check 63873-Scientific misconduct check.pdf
Scientific Editor Work List 63873-Scientific editor work list.pdf