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12/27/2021 5:24:00 AM | Browse: 317 | Download: 568
Publication Name World Journal of Hepatology
Manuscript ID 64333
Country/Territory Egypt
Received
2021-05-04 16:36
Peer-Review Started
2021-05-04 16:38
To Make the First Decision
Return for Revision
2021-06-17 20:11
Revised
2021-06-21 23:26
Second Decision
2021-10-26 07:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-10-27 03:22
Articles in Press
2021-10-27 03:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-10-15 22:42
Typeset the Manuscript
2021-12-13 08:53
Publish the Manuscript Online
2021-12-27 05:24
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title New stem cell autophagy surrogate diagnostic biomarkers in early-stage hepatocellular carcinoma in Egypt: A pilot study
Manuscript Source Invited Manuscript
All Author List Tarek Yosef, Wesam Ahmed Ibrahim, Marwa Matboli, Amina Ahmed Swilam and Sarah El-Nakeep
ORCID
Author(s) ORCID Number
Tarek Yosef http://orcid.org/0000-0002-0003-7548
Wesam Ahmed Ibrahim http://orcid.org/0000-0003-1813-5248
Marwa Matboli http://orcid.org/0000-0002-6852-3954
Amina Ahmed Swilam http://orcid.org/0000-0002-1464-1269
Sarah El-Nakeep http://orcid.org/0000-0003-2830-5052
Funding Agency and Grant Number
Funding Agency Grant Number
Corresponding Author Sarah El-Nakeep, MD, Associate Professor, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Ramsees Street, Cairo 11591, Egypt. sarahnakeep@gmail.com
Key Words Autophagy; Hepatocellular carcinoma; miRNA; miR-519d; Stem cell; SQSTM1
Core Tip Hepatocellular carcinoma (HCC) is the most common primary liver cancer. HCC is associated with poor prognosis due to difficult discovery at an early stage. The molecular pathophysiology behind HCC is not yet fully understood. Autophagy is one of the important affected pathways in HCC pathogenesis. In this study we used Insilco analysis to determine a new molecular pathway and find the background controlling genetic and epigentic pathways underlying. We found that autophagy-controlling gene SQSTM1 is related to hsa-miR-519d-3p. Also, we found that their use as early detecting biomarkers for HCC diagnosis are more efficient than the current alpha-fetoprotein.
Publish Date 2021-12-27 05:24
Citation Yosef T, Ibrahim WA, Matboli M, Swilam AA, El-Nakeep S. New stem cell autophagy surrogate diagnostic biomarkers in early-stage hepatocellular carcinoma in Egypt: A pilot study. World J Hepatol 2021; 13(12): 2137-2149
URL https://www.wjgnet.com/1948-5182/full/v13/i12/2137.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i12.2137
Full Article (PDF) WJH-13-2137.pdf
Full Article (Word) WJH-13-2137.docx
Manuscript File 64333_Auto_Edited-JRF-Filipodia CL.docx
Answering Reviewers 64333-Answering reviewers.pdf
Audio Core Tip 64333-Audio core tip.mp3
Biostatistics Review Certificate 64333-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 64333-Conflict-of-interest statement.pdf
Copyright License Agreement 64333-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 64333-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 64333-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 64333-Language certificate.pdf
Peer-review Report 64333-Peer-review(s).pdf
Scientific Misconduct Check 64333-Bing-Fan JR-2.png
Scientific Editor Work List 64333-Scientific editor work list.pdf