Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64614
Country	Japan

Received	2021-02-21 08:56
Peer-Review Started	2021-02-21 08:59
To Make the First Decision
Return for Revision	2021-05-08 04:11
Revised	2021-06-03 13:45
Second Decision	2021-08-11 03:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-11 07:37
Articles in Press	2021-08-11 07:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-02 08:25
Publish the Manuscript Online	2021-09-10 12:09

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression
Manuscript Source	Invited Manuscript
All Author List	Motomichi Fujita, Hideo Suzuki and Fumio Fukai
ORCID	Author(s) ORCID Number Motomichi Fujita http://orcid.org/0000-0001-7502-9797 Hideo Suzuki http://orcid.org/0000-0002-1469-7449 Fumio Fukai http://orcid.org/0000-0002-5646-167X
Funding Agency and Grant Number
Corresponding Author	Fumio Fukai, PhD, Professor, Department of Molecular Patho-Physiology, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Chiba, Japan. fukai@rs.noda.tus.ac.jp
Key Words	Tenascin-C; TNIIIA2; Beta1-integrin; Integrin activation; Colitis-associated colorectal cancer; Colon cancer
Core Tip	Exposure of the cryptic functional site TNIIIA2 from the Tenascin-C (TNC) molecule and its potent and sustained activation of beta1-integrins appear to be associated with the development of colon cancer and its malignant progression. Inhibition of the biological function of TNIIIA2 derived from TNC molecule may be a promising strategy for the prevention and treatment of colon cancer.
Publish Date	2021-09-10 12:09
Citation	Fujita M, Suzuki H, Fukai F. Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression. World J Gastrointest Oncol 2021; 13(9): 980-994
URL	https://www.wjgnet.com/1948-5204/full/v13/i9/980.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i9.980

Full Article (PDF)	WJGO-13-980.pdf
Full Article (Word)	WJGO-13-980.docx
Manuscript File	64614_Auto_Edited-JPY.docx
Answering Reviewers	64614-Answering reviewers.pdf
Audio Core Tip	64614-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64614-Conflict-of-interest statement.pdf
Copyright License Agreement	64614-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64614-Language certificate.pdf
Peer-review Report	64614-Peer-review(s).pdf
Scientific Misconduct Check	64614-Bing-Wang JL-1.jpg
Scientific Misconduct Check	64614-Bing-Fan JR-2.png
Scientific Misconduct Check	64614-Scientific misconduct check.pdf
Scientific Editor Work List	64614-Scientific editor work list.pdf