Publication Name	World Journal of Gastroenterology
Manuscript ID	6463
Country	Italy

Received	2013-10-19 10:43
Peer-Review Started	2013-10-22 09:11
To Make the First Decision	2013-12-16 17:43
Return for Revision	2014-03-10 08:44
Revised	2014-01-23 23:43
Second Decision	2014-04-29 12:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-29 14:15
Articles in Press	2014-05-23 11:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-06 23:26
Typeset the Manuscript	2014-07-22 17:08
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Helicobacter pylori infection and drugs malabsorption
Manuscript Source	Invited Manuscript
All Author List	Edith Lahner, Camilla Virili, Maria Giulia Santaguida, Bruno Annibale and Marco Centanni
Funding Agency and Grant Number	Funding Agency Grant Number “Sapienza” University of Roma grant 0006345
Corresponding Author	Marco Centanni, MD, Professor, Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Roma, Viale Regina Elena 324, 00161 Roma, Italy. marco.centanni@uniroma1.it
Key Words	Drug malabsorption; Helicobacter pylori gastritis; Gastric hypoacidity; Thyroxine treatment; Thyroxine malabsorption; Human immunodeficiency virus; Delavirdine; L-dopa; Parkinson’s disease; Ketaconazole
Core Tip	Drug absorption is a critical factor affecting the efficacy of orally administered therapies. A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori (H. pylori) infection has been proposed. Previous studies have observed that H. pylori infection and poor bioavailability of l-dopa and l-thyroxine are associated. Less strong seems the association between H. pylori infection and delavirdine and ketoconazole malabsorption. The absorption of oral drugs may potentially be influenced by gastric pH. When a treatment with an oral drug fails, this may be due to a H. pylori-related gastritis and its associated gastric hypochlorhydria, which may partially or totally be reversible.
Publish Date	2014-08-18 16:49
Citation	Lahner E, Virili C, Santaguida MG, Annibale B, Centanni M. Helicobacter pylori infection and drugs malabsorption. World J Gastroenterol 2014; 20(30): 10331-10337
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10331.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10331

Full Article (PDF)	WJG-20-10331.pdf
Full Article (Word)	WJG-20-10331.doc
Manuscript File	6463-Review.doc
Answering Reviewers	6463-Answering reviewers.pdf
Copyright License Agreement	6463-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6463-Language certificate.pdf
Peer-review Report	6463-Peer review(s).pdf
Scientific Editor Work List	6463-Scientific editor work list.pdf