Publication Name	World Journal of Clinical Oncology
Manuscript ID	64718
Country	Germany

Received	2021-02-23 13:47
Peer-Review Started	2021-02-23 13:54
To Make the First Decision
Return for Revision	2021-07-29 07:49
Revised	2021-09-07 12:04
Second Decision	2022-02-18 05:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-02-20 13:21
Articles in Press	2022-02-20 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-14 00:23
Publish the Manuscript Online	2022-03-24 09:40

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Intestinal Wnt in the transition from physiology to oncology
Manuscript Source	Invited Manuscript
All Author List	Julia Swoboda, Patrick Mittelsdorf, Yuan Chen, Ralf Weiskirchen, Johannes Stallhofer, Silke Schüle and Nikolaus Gassler
ORCID	Author(s) ORCID Number Julia Swoboda http://orcid.org/0000-0001-8525-4648 Patrick Mittelsdorf http://orcid.org/0000-0002-0142-4118 Yuan Chen http://orcid.org/0000-0002-4752-9222 Ralf Weiskirchen http://orcid.org/0000-0003-3888-0931 Johannes Stallhofer http://orcid.org/0000-0001-8698-6103 Silke Schüle http://orcid.org/0000-0002-5640-187X Nikolaus Gassler http://orcid.org/0000-0002-7351-258X
Funding Agency and Grant Number
Corresponding Author	Nikolaus Gassler, MA, MD, Professor, Section Pathology, Institute of Forensic Medicine, Jena University Hospital, Am Klinikum 1, Jena 07747, Germany. nikolaus.gassler@med.uni-jena.de
Key Words	Wnt signaling; Beta-catenin; Intestine; Colorectal cancer; Cell signaling; Intestinal stem cells
Core Tip	Wnt signaling pathway is a key regulator of intestinal stem cells. Mutations in this pathway are frequently found in adenomas and carcinomas of the colorectum. Therefore, it represents a potential target for anticancer therapy. This review sums up the physiological role and the regulatory mechanism of Wnt signaling in the human intestine, and moreover, discusses the central role of the Wnt signaling pathway in intestinal carcinogenesis, the morphological features associated with Wnt hyperactivation and clinical relevance of Wnt in the colorectal carcinoma.
Publish Date	2022-03-24 09:40
Citation	Swoboda J, Mittelsdorf P, Chen Y, Weiskirchen R, Stallhofer J, Schüle S, Gassler N. Intestinal Wnt in the transition from physiology to oncology. World J Clin Oncol 2022; 13(3): 168-185
URL	https://www.wjgnet.com/2218-4333/full/v13/i3/168.htm
DOI	https://dx.doi.org/10.5306/wjco.v13.i3.168

Full Article (PDF)	WJCO-13-168.pdf
Full Article (Word)	WJCO-13-168.docx
Manuscript File	64718_Auto_Edited.docx
Answering Reviewers	64718-Answering reviewers.pdf
Audio Core Tip	64718-Audio core tip.wav
Conflict-of-Interest Disclosure Form	64718-Conflict-of-interest statement.pdf
Copyright License Agreement	64718-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64718-Language certificate.pdf
Peer-review Report	64718-Peer-review(s).pdf
Scientific Misconduct Check	64718-Bing-Wang JJ-2.png
Scientific Editor Work List	64718-Scientific editor work list.pdf