Publication Name	World Journal of Stem Cells
Manuscript ID	64960
Country	Switzerland

Received	2021-02-25 19:17
Peer-Review Started	2021-02-25 19:22
To Make the First Decision
Return for Revision	2021-04-20 01:56
Revised	2021-05-02 09:20
Second Decision	2021-06-04 08:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-04 09:18
Articles in Press	2021-06-04 09:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-11 20:48
Typeset the Manuscript	2021-06-23 03:30
Publish the Manuscript Online	2021-06-26 07:48

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	Harpreet K Mandhair, Urban Novak and Ramin Radpour
ORCID	Author(s) ORCID Number Harpreet K Mandhair http://orcid.org/0000-0001-8753-7078 Urban Novak http://orcid.org/0000-0001-7642-2101 Ramin Radpour http://orcid.org/0000-0002-5632-7833
Funding Agency and Grant Number
Corresponding Author	Ramin Radpour, MSc, PhD, Lecturer, Senior Scientist, Department for BioMedical Research, University of Bern, Murtenstrasse 35, Bern 3008, Switzerland. ramin.radpour@dbmr.unibe.ch
Key Words	Autophagy; Cancer stem cells; Cancer cells; Epigenetics; Histone remodeling; DNA methylation; Non-coding RNA
Core Tip	Cancer stem cells (CSCs) are a distinct population in the tumor bulk with enhanced self-renewal capability. Autophagy primarily exerts oncogenic activity and adaptive signals during cancer progression. Similarly, epigenetic modifications display a crucial role in tumor initiation and cancer development through its regulation of tumor suppressor genes and oncogenes. Emerging studies report epigenetic modifications regulate autophagy and metabolic pathways promoting tumor growth, elicit immunosuppressive activity and contribute to therapy resistance. Therefore, understanding this complex signaling patterns can theoretically lead to a more efficient and targeted cancer treatment.
Publish Date	2021-06-26 07:48
Citation	Mandhair HK, Novak U, Radpour R. Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells. World J Stem Cells 2021; 13(6): 542-567
URL	https://www.wjgnet.com/1948-0210/full/v13/i6/542.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i6.542

Full Article (PDF)	WJSC-13-542.pdf
Full Article (Word)	WJSC-13-542.docx
Manuscript File	64960-Review-FilipodiaCL .docx
Answering Reviewers	64960-Answering reviewers.pdf
Audio Core Tip	64960-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	64960-Conflict-of-interest statement.pdf
Copyright License Agreement	64960-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64960-Language certificate.pdf
Peer-review Report	64960-Peer-review(s).pdf
Scientific Misconduct Check	64960-Scientific misconduct check.pdf
Scientific Editor Work List	64960-Scientific editor work list.pdf