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9/29/2021 11:12:00 AM | Browse: 393 | Download: 738
Publication Name World Journal of Gastroenterology
Manuscript ID 65240
Country/Territory China
Received
2021-03-02 10:11
Peer-Review Started
2021-03-02 10:22
To Make the First Decision
Return for Revision
2021-04-17 22:33
Revised
2021-04-29 11:21
Second Decision
2021-08-09 02:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-08-09 09:16
Articles in Press
2021-08-09 09:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-08-27 08:00
Typeset the Manuscript
2021-09-27 00:15
Publish the Manuscript Online
2021-09-29 11:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Increased systemic RNA oxidative damage and the diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection
Manuscript Source Invited Manuscript
All Author List Jing-Jing Nie, Ya-Ya Pian, Ji-Hong Hu, Guo-Qing Fan, Lv-Tao Zeng, Qiu-Geng Ouyang, Zhen-Xiang Gao, Zhen Liu, Chen-Chen Wang, Qian Liu and Jian-Ping Cai
ORCID
Author(s) ORCID Number
Jing-Jing Nie http://orcid.org/0000-0002-6563-1175
Ya-Ya Pian http://orcid.org/0000-0002-1519-3947
Ji-Hong Hu http://orcid.org/0000-0002-5433-954X
Guo-Qing Fan http://orcid.org/0000-0001-9122-5149
Lv-Tao Zeng http://orcid.org/0000-0002-2252-5110
Qiu-Geng Ouyang http://orcid.org/0000-0001-6348-5066
Zhen-Xiang Gao http://orcid.org/0000-0001-7037-206X
Zhen Liu http://orcid.org/0000-0003-4672-7515
Chen-Chen Wang http://orcid.org/0000-0001-5763-7174
Qian Liu http://orcid.org/0000-0003-4610-2531
Jian-Ping Cai http://orcid.org/0000-0003-2793-9221
Funding Agency and Grant Number
Funding Agency Grant Number
CAMS Innovation Fund for Medical Sciences 2018-I2M-1-002
National Key R&D Program of China 2018YFC2000300
Corresponding Author Jian-Ping Cai, PhD, Professor, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dahua Road, Dongcheng District, Beijing 100730, China. caijp61@vip.sina.com
Key Words 8-oxo-7,8-dihydroguanosine; Shigella flexneri; Infection; Oxidative damage
Core Tip Shigella flexneri (S. flexneri) is a major pathogen causing acute intestinal infection, but the systematic oxidative damage incurred during the course of infection has not been investigated. To establish a Sprague-Dawley rat model with S. flexneri infection in the intestine, we found that 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) levels were markedly increased in the colon, ileum, liver, spleen and brain after infection, showing that S. flexneri can exacerbate systemic RNA oxidation. The changing trend in levels of urinary 8-oxo-Gsn (as the RNA oxidative metabolites) was consistent with the changes in the white blood cells count, C-reactive protein level and cytokine level during infection. Urinary 8-oxo-Gsn may be useful as a biomarker for evaluating the severity and prognosis of infection.
Publish Date 2021-09-29 11:12
Citation Nie JJ, Pian YY, Hu JH, Fan GQ, Zeng LT, Ouyang QG, Gao ZX, Liu Z, Wang CC, Liu Q, Cai JP. Increased systemic RNA oxidative damage and diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection. World J Gastroenterol 2021; 27(37): 6248-6261
URL https://www.wjgnet.com/1007-9327/full/v27/i37/6248.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i37.6248
Full Article (PDF) WJG-27-6248.pdf
Full Article (Word) WJG-27-6248.docx
The ARRIVE Guidelines 65240-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 65240_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers 65240-Answering reviewers.pdf
Audio Core Tip 65240-Audio core tip.m4a
Biostatistics Review Certificate 65240-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 65240-Conflict-of-interest statement.pdf
Copyright License Agreement 65240-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 65240-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 65240-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 65240-Language certificate.pdf
Supplementary Material 65240-Supplementary material.pdf
Peer-review Report 65240-Peer-review(s).pdf
Scientific Misconduct Check 65240-Bing-Wang JL-1.jpg
Scientific Misconduct Check 65240-Scientific misconduct check.pdf
Scientific Editor Work List 65240-Scientific editor work list.pdf