ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Increased systemic RNA oxidative damage and the diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection
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Manuscript Source |
Invited Manuscript |
All Author List |
Jing-Jing Nie, Ya-Ya Pian, Ji-Hong Hu, Guo-Qing Fan, Lv-Tao Zeng, Qiu-Geng Ouyang, Zhen-Xiang Gao, Zhen Liu, Chen-Chen Wang, Qian Liu and Jian-Ping Cai |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
CAMS Innovation Fund for Medical Sciences |
2018-I2M-1-002 |
National Key R&D Program of China |
2018YFC2000300 |
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Corresponding Author |
Jian-Ping Cai, PhD, Professor, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dahua Road, Dongcheng District, Beijing 100730, China. caijp61@vip.sina.com |
Key Words |
8-oxo-7,8-dihydroguanosine; Shigella flexneri; Infection; Oxidative damage |
Core Tip |
Shigella flexneri (S. flexneri) is a major pathogen causing acute intestinal infection, but the systematic oxidative damage incurred during the course of infection has not been investigated. To establish a Sprague-Dawley rat model with S. flexneri infection in the intestine, we found that 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) levels were markedly increased in the colon, ileum, liver, spleen and brain after infection, showing that S. flexneri can exacerbate systemic RNA oxidation. The changing trend in levels of urinary 8-oxo-Gsn (as the RNA oxidative metabolites) was consistent with the changes in the white blood cells count, C-reactive protein level and cytokine level during infection. Urinary 8-oxo-Gsn may be useful as a biomarker for evaluating the severity and prognosis of infection. |
Publish Date |
2021-09-29 11:12 |
Citation |
Nie JJ, Pian YY, Hu JH, Fan GQ, Zeng LT, Ouyang QG, Gao ZX, Liu Z, Wang CC, Liu Q, Cai JP. Increased systemic RNA oxidative damage and diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection. World J Gastroenterol 2021; 27(37): 6248-6261 |
URL |
https://www.wjgnet.com/1007-9327/full/v27/i37/6248.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v27.i37.6248 |