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Articles Published Processes
7/15/2021 10:19:10 AM | Browse: 467 | Download: 837
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Received |
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2021-03-07 21:56 |
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Peer-Review Started |
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2021-03-07 22:01 |
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To Make the First Decision |
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Return for Revision |
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2021-03-30 04:16 |
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Revised |
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2021-04-13 21:37 |
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Second Decision |
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2021-05-10 09:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-05-10 09:56 |
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Articles in Press |
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2021-05-10 09:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-07 04:56 |
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Typeset the Manuscript |
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2021-06-30 09:49 |
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Publish the Manuscript Online |
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2021-07-15 10:19 |
ISSN |
2220-3206 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Neurosciences |
Manuscript Type |
Review |
Article Title |
Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule
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Manuscript Source |
Invited Manuscript |
All Author List |
Adejoke Yetunde Onaolapo and Olakunle James Onaolapo |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Olakunle James Onaolapo, MBBS, MSc, PhD, Senior Lecturer, Behavioural Neuroscience Unit, Neuropharmacology Subdivision, Department of Pharmacology, Ladoke Akintola University of Technology, P.M.B 4000, Osun State 234, Nigeria. olakunleonaolapo@yahoo.co.uk |
Key Words |
Brain; Gut microbiome; Mental health; Mood disorders; Neurotransmitters |
Core Tip |
The versatility of glutamate as the brain’s foremost excitatory neurotransmitter, and modulator of intermediary metabolism in the gastrointestinal tract is considered common knowledge. Years of research suggest glutamate has a role to play in depression. Also, there is increasing evidence of a possible relationship between glutamate and the pathophysiology and/or treatment of depression. The complexity of depression suggests dysregulation of glutamate in sites such as the gastrointestinal tract and brain. The communication link involving dietary glutamate, the gut, endogenous glutamate, and the brain is a multidirectional pathway; the understanding of which is necessary to fully account for glutamate’s role in depression. |
Publish Date |
2021-07-15 10:19 |
Citation |
Onaolapo AY, Onaolapo OJ. Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule. World J Psychiatr 2021; 11(7): 297-315 |
URL |
https://www.wjgnet.com/2220-3206/full/v11/i7/297.htm |
DOI |
https://dx.doi.org/10.5498/wjp.v11.i7.297 |
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