Publication Name	World Journal of Gastroenterology
Manuscript ID	6564
Country	Sweden

Received	2013-10-24 14:20
Peer-Review Started	2013-10-25 17:40
To Make the First Decision	2014-01-09 13:36
Return for Revision	2014-01-10 11:21
Revised
Second Decision	2014-05-05 08:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-05 09:47
Articles in Press	2014-05-23 10:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-30 19:08
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Observational Study
Article Title	Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Sezin Günaltay, Nils Nyhlin, Ashok Kumar Kumawat, Curt Tysk, Johan Bohr, Olof Hultgren and Elisabeth Hultgren Hörnquist
Funding Agency and Grant Number	Funding Agency Grant Number Research Committee of Örebro County Council Örebro University to Sezin Günaltay
Corresponding Author	Sezin Günaltay, MSc, Department of Biomedicine, School of Health and Medical Sciences, Örebro University, SE-701 82 Örebro, Sweden. sezin.gunaltay@oru.se
Key Words	Interleukin-37; MicroRNA; Lymphocytic colitis; Collagenous colitis; Ulcerative colitis
Core Tip	Epithelial destruction is observed in both microscopic and ulcerative colitis, likely resulting in enhanced contact between gut microbiota and Toll-like receptors (TLRs), which do not normally face the lumen. Insufficiently regulated TLR signaling may result in chronic inflammation. In this study, we analyzed several important regulatory molecules of TLR signaling: interleukin-1 receptor-associated kinase (IRAK)-2, IRAK-M, interleukin (IL)-37, microRNA (miR)-146a, miR-155, and miR-21. A possible association between the regulatory effects of IRAK-M and miR-146a was revealed in both diseases. This novel analysis of miR-155 and miR-21 in microscopic and ulcerative colitis revealed different expressions in active disease and remission.
Publish Date	2014-09-18 19:50
Citation	Günaltay S, Nyhlin N, Kumawat AK, Tysk C, Bohr J, Hultgren O, Hultgren Hörnquist E. Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis. World J Gastroenterol 2014; 20(34): 12249-12259
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/12249.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.12249

Full Article (PDF)	WJG-20-12249.pdf
Full Article (Word)	WJG-20-12249.doc
Manuscript File	6564-Review.docx
Answering Reviewers	6564-Answering reviewers.pdf
Copyright License Agreement	6564-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131023194909.pdf
Non-Native Speakers of English Editing Certificate	6564-Language certificate.pdf
Peer-review Report	6564-Peer review(s).pdf
Scientific Editor Work List	6564-Scientific editor work list.pdf