Publication Name	World Journal of Gastroenterology
Manuscript ID	6575
Country	United Kingdom

Received	2013-10-24 16:27
Peer-Review Started	2013-10-25 18:17
To Make the First Decision	2013-12-26 11:19
Return for Revision	2013-12-26 20:03
Revised	2014-01-14 03:20
Second Decision	2014-04-03 10:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-03 11:27
Articles in Press	2014-05-23 10:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-25 11:23
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis
Manuscript Source	Invited Manuscript
All Author List	Jun Wei Lim, John Dillon and Michael Miller
Funding Agency and Grant Number
Corresponding Author	Michael Miller, MBChB, MRCP, PhD, Specialist Registrar, Department of Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom. m.miller@dundee.ac.uk
Key Words	Non-alcoholic fatty liver disease; Proteomics; Genomics; Metabolic syndrome; Pathophysiology
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder in Western populations. NAFLD can occur as a spectrum diseases, from simple steatosis, to non-alcoholic steatohepatitis characterised by hepatocellular injury and inflammation, to cirrhosis and hepatocellular carcinoma. This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis. This review highlighted several functional proteins and genetic polymoprhisms; particular those involved in insulin resistance, triglycerides metabolism and hepatic inflammation. It is hoped that this review will offer further insights into the pathophysiology of NAFLD.
Publish Date	2014-07-14 17:39
Citation	Lim JW, Dillon J, Miller M. Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis. World J Gastroenterol 2014; 20(26): 8325-8340
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8325.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8325

Full Article (PDF)	WJG-20-8325.pdf
Full Article (Word)	WJG-20-8325.doc
Manuscript File	6575-Review.docx
Answering Reviewers	6575-Answering reviewers.pdf
Copyright License Agreement	6575-Copyright assignment.pdf
Peer-review Report	6575-Peer review(s).pdf
Scientific Editor Work List	6575-Scientific editor work list.doc