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2/17/2022 8:22:35 AM | Browse: 351 | Download: 592
Publication Name World Journal of Psychiatry
Manuscript ID 65951
Country/Territory Thailand
Received
2021-03-18 08:24
Peer-Review Started
2021-03-18 08:30
To Make the First Decision
Return for Revision
2021-07-15 02:33
Revised
2021-08-14 05:14
Second Decision
2022-01-10 05:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-10 22:59
Articles in Press
2022-01-10 22:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-01-05 21:28
Typeset the Manuscript
2022-02-09 08:07
Publish the Manuscript Online
2022-02-17 08:22
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Observational Study
Article Title Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis
Manuscript Source Invited Manuscript
All Author List Ana Paula Michelin, Michael H J Maes, Thitiporn Supasitthumrong, Chusak Limotai, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefânia Gastaldello Moreira, Buranee Kanchanatawan and Décio Sabbatini Barbosa
ORCID
Author(s) ORCID Number
Ana Paula Michelin http://orcid.org/0000-0001-5197-0638
Michael H J Maes http://orcid.org/0000-0002-2012-871X
Thitiporn Supasitthumrong http://orcid.org/0000-0001-6555-0781
Chusak Limotai http://orcid.org/0000-0002-3136-9199
Andressa Keiko Matsumoto http://orcid.org/0000-0001-9385-0722
Laura de Oliveira Semeão http://orcid.org/0000-0001-8096-7307
João Victor de Lima Pedrão http://orcid.org/0000-0001-6867-2370
Estefânia Gastaldello Moreira http://orcid.org/0000-0001-8362-9557
Buranee Kanchanatawan http://orcid.org/0000-0002-5387-8867
Décio Sabbatini Barbosa http://orcid.org/0000-0002-8677-4730
Funding Agency and Grant Number
Funding Agency Grant Number
atchadapisek Research Funds, Faculty of Medicine, Chulalongkorn University RA60/042
atchadapisek Research Funds, Faculty of Medicine, Chulalongkorn University RA61/050
Corresponding Author Michael H J Maes, MD, PhD, Professor, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Patumwan 1873, Bangkok 10330, Thailand. dr.michaelmaes@hotmail.com
Key Words Antioxidants; Oxidative stress; Neuroimmune; Major depression; Mood disorders; Affective disorders
Core Tip The severity of temporal lobe epilepsy (TLE) and mesial temporal sclerosis and their psychiatric comorbidities including depression, anxiety and psychosis are largely explained by lowered paraoxonase 1 (PON1) enzyme activities, which mediate the effects of the Q192R PON1 genotype on psychopathology and epilepsy severity. It is argued that PON1 status may play a key role in the pathophysiology of TLE, medial temporal sclerosis and its psychiatric comorbidities by increasing the risk of neuro-oxidative toxicity. It is concluded that PON1 enzyme activities are new drug targets to treat seizure frequency and psychiatric comorbidities in patients with TLE.
Publish Date 2022-02-17 08:22
Citation Michelin AP, Maes MHJ, Supasitthumrong T, Limotai C, Matsumoto AK, de Oliveira Semeão L, de Lima Pedrão JV, Moreira EG, Kanchanatawan B, Barbosa DS. Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis. World J Psychiatry 2022; 12(2): 308-322
URL https://www.wjgnet.com/2220-3206/full/v12/i2/308.htm
DOI https://dx.doi.org/10.5498/wjp.v12.i2.308
Full Article (PDF) WJP-12-308.pdf
Full Article (Word) WJP-12-308.docx
Manuscript File 65951_Auto_Edited-JRF-Filipodia CL.docx
Answering Reviewers 65951-Answering reviewers.pdf
Biostatistics Review Certificate 65951-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 65951-Conflict-of-interest statement.pdf
Copyright License Agreement 65951-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 65951-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 65951-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 65951-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 65951-Language certificate.pdf
Peer-review Report 65951-Peer-review(s).pdf
Scientific Misconduct Check 65951-Bing-Fan JR-2.png
Scientific Editor Work List 65951-Scientific editor work list.pdf