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1/11/2022 8:34:26 AM | Browse: 258 | Download: 399
Publication Name World Journal of Gastroenterology
Manuscript ID 66013
Country/Territory Japan
Received
2021-03-26 08:19
Peer-Review Started
2021-03-26 08:24
To Make the First Decision
Return for Revision
2021-06-14 01:35
Revised
2021-06-25 03:59
Second Decision
2021-12-31 03:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-12-31 21:59
Articles in Press
2021-12-31 21:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-12-08 15:16
Typeset the Manuscript
2022-01-05 07:25
Publish the Manuscript Online
2022-01-11 08:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer
Manuscript Source Invited Manuscript
All Author List Kohji Yamada and Kiyotsugu Yoshida
ORCID
Author(s) ORCID Number
Kohji Yamada http://orcid.org/0000-0001-9493-5269
Kiyotsugu Yoshida http://orcid.org/0000-0003-3108-7383
Funding Agency and Grant Number
Funding Agency Grant Number
Japan Society for the Promotion of Science, KAKENHI Grant 19H03519
Japan Society for the Promotion of Science, KAKENHI Grant 16K18434
Japan Society for the Promotion of Science, KAKENHI Grant 18K19484
Japan Society for the Promotion of Science, KAKENHI Grant 17H03584
Japan Society for the Promotion of Science, KAKENHI Grant 18K15253
Japan Society for the Promotion of Science, KAKENHI Grant 20H03519
AMED under Grant A326TS
The Jikei University Graduate Research Fund
Science Research Promotion Fund
Corresponding Author Kiyotsugu Yoshida, MD, PhD, Professor, Department of Biochemistry, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Tokyo 105-8461, Japan. kyoshida@jikei.ac.jp
Key Words PKCδ; Liver cancer; Subcellular localization; Tumor suppression; Tumor progression
Core Tip Protein kinase Cδ (PKCδ) plays multifunctional roles in various cancers, including liver cancer. PKCδ has been shown to exert pleiotropic functions through various stimuli responsiveness, post-translational modifications, and subcellular localization. Recently, we found that PKCδ is secreted extracellularly and resides on the cell surface of liver cancer cells, which contributes to tumorigenesis. In this review, we focus on the localization of PKCδ to discuss its characteristic localization patterns and functions in liver cancer, and outline the involvement of PKCδ localized intra- and extracellularly with distinct functions in the progression of liver cancer.
Publish Date 2022-01-11 08:34
Citation Yamada K, Yoshida K. Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer. World J Gastroenterol 2022; 28(2): 188-198
URL https://www.wjgnet.com/1007-9327/full/v28/i2/188.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i2.188
Full Article (PDF) WJG-28-188.pdf
Full Article (Word) WJG-28-188.docx
Manuscript File 66013_Auto_Edited.docx
Answering Reviewers 66013-Answering reviewers.pdf
Audio Core Tip 66013-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 66013-Conflict-of-interest statement.pdf
Copyright License Agreement 66013-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 66013-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 66013-Language certificate.pdf
Peer-review Report 66013-Peer-review(s).pdf
Scientific Misconduct Check 66013-Bing-Yan JP-1.jpg
Scientific Editor Work List 66013-Scientific editor work list.pdf