| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Feng Shen, Rui-Dan Zheng, Yu-Qiang Mi, Xiao-Ying Wang, Qin Pan, Guang-Yu Chen, Hai-Xia Cao, Ming-Li Chen, Liang Xu, Jian-Neng Chen, Yi Cao, Rui-Nan Zhang, Lei-Ming Xu and Jian-Gao Fan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Basic Research Project |
2012CB517501 |
| Chinese Foundation for Hepatitis Prevention and Control –“WANG Bao-En” Liver Fibrosis Research Fund |
XJS20120501 |
| Shanghai Science and Technology Committee |
09140903500 |
| Shanghai Science and Technology Committee |
10411956300 |
| 100-Talents Program of the Shanghai Municipal Health Bureau |
XBR2011007 |
|
| Corresponding Author |
Jian-Gao Fan, MD, PhD, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@gmail.com |
| Key Words |
Fatty liver; Nonalcoholic; Controlled attenuation parameter; Transient elastography; Chronic hepatitis B |
| Core Tip |
We introduced a novel controlled attenuation parameter (CAP) which was acquired using the FibroScan equipped with the M probe. This multi-center prospective cohort study was performed in Chinese nonalcoholic fatty liver disease or chronic hepatitis B patients. Following multivariate linear regression analysis, we found that CAP was significantly correlated with steatosis grade and was not influenced by inflammation, fibrosis or aetiology. Although it is less effective in identifying moderate to severe steatosis and limited by body mass index, we believe that CAP values are more useful than the measurement of 5% steatosis and may be used as a substitute for ultrasonography in epidemiological investigations of fatty liver. |
| Publish Date |
2014-04-29 09:53 |
| Citation |
Shen F, Zheng RD, Mi YQ, Wang XY, Pan Q, Chen GY, Cao HX, Chen ML, Xu L, Chen JN, Cao Y, Zhang RN, Xu LM, Fan JG. Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients. World J Gastroenterol 2014; 20(16): 4702-4711 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i16/4702.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i16.4702 |
