Publication Name	World Journal of Gastroenterology
Manuscript ID	6642
Country	Japan

Received	2013-10-26 11:30
Peer-Review Started	2013-10-27 11:33
To Make the First Decision	2014-01-09 12:35
Return for Revision	2014-01-11 19:05
Revised	2014-01-25 11:44
Second Decision	2014-06-26 16:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-26 17:34
Articles in Press	2014-06-26 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-09 20:02
Publish the Manuscript Online	2014-10-07 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Short- and long-term outcome of interferon therapy for chronic hepatitis B infection
Manuscript Source	Invited Manuscript
All Author List	Yasushi Seo and Yoshihiko Yano
Funding Agency and Grant Number
Corresponding Author	Yasushi Seo, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. yseo@med.kobe-u.ac.jp
Key Words	Chronic hepatitis B; Hepatitis B virus; Interferon ; Long-term outcome; Hepatocellular carcinoma
Core Tip	The long-term ability of interferon (IFN)-? treatment of chronic hepatitis B virus (HBV) infections to prevent new cirrhosis, complications associated with cirrhosis, and development of hepatocellular carcinoma (HCC) is controversial. The beneficial effect of IFN-? treatment in reducing the development of HCC has mainly been observed in treatment responders who already have cirrhosis. These inconsistent findings may be due to the inevitable limitations of comparisons across studies, including differences in the baseline characteristics of the study and the moderate suppression of HBV replication by IFN-? relative to nucleoside/nucleotide analogs.
Publish Date	2014-10-07 17:32
Citation	Seo Y, Yano Y. Short- and long-term outcome of interferon therapy for chronic hepatitis B infection. World J Gastroenterol 2014; 20(37): 13284-13292
URL	http://www.wjgnet.com/1007-9327/full/v20/i37/13284.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i37.13284

Full Article (PDF)	WJG-20-13284.pdf
Full Article (Word)	WJG-20-13284.doc
Manuscript File	6642-Review.docx
Answering Reviewers	6642-Answering reviewers.PDF
Copyright License Agreement	6642-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	6642-Language certificate.pdf
Peer-review Report	6642-Peer review(s).pdf
Scientific Misconduct Check	6642-CrossCheck.jpg
Scientific Editor Work List	6642-Scientific editor work list.pdf