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8/29/2014 2:41:00 PM | Browse: 1089 | Download: 936
Publication Name World Journal of Gastroenterology
Manuscript ID 6643
Country/Territory Spain
Received
2013-10-26 11:34
Peer-Review Started
2013-10-27 11:42
To Make the First Decision
2013-12-16 17:50
Return for Revision
2013-12-17 16:27
Revised
2014-01-24 21:58
Second Decision
2014-03-10 15:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-10 17:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-31 15:27
Publish the Manuscript Online
2014-04-14 10:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Proteomics for discovery of candidate colorectal cancer biomarkers
Manuscript Source Invited Manuscript
All Author List Paula Álvarez-Chaver, Olalla Otero-Estévez, María Páez de la Cadena, Francisco J Rodríguez-Berrocal and Vicenta S Martínez-Zorzano
Funding Agency and Grant Number
Funding Agency Grant Number
Xunta de Galicia 10PXIB310215PR
REGICC CN 2012/217
Fundación Científica de la Asociación Española contra el Cáncer GCB13131592CAST
Fondo de Investigaciones Sanitarias PI12/00117
FEDER
Corresponding Author Vicenta S Martínez-Zorzano, PhD, Área de Bioquímica y Biología Molecular, Departamento de Bioquímica, Genética e Inmunología, Facultad de Biología, Universidad de Vigo, Campus As Lagoas-Marcosende, 36310 Vigo (Pontevedra), Spain. vzorzano@uvigo.es
Key Words Colorectal cancer; Serum; Tissue; Proteins; Biomarkers; Proteomics; Protein identification; Mass spectrometry
Core Tip Proteomics is an important tool for the identification of candidate cancer biomarkers since it allows the simultaneous analysis of multiple differentially expressed proteins in a single study. This review provides an overview of recent reports focused on the different proteomic tools used for the discovery of candidate protein markers for colorectal cancer (CRC), such as two-dimensional electrophoresis methods, quantitative mass spectrometry-based techniques or protein microarrays. We also emphasize the use of different samples including cell lines, murine models, clinical samples as tissue, serum or faeces, for CRC biomarker discovery, discussing their advantages and disadvantages, and finally summarize the candidate CRC markers most frequently identified.
Publish Date 2014-04-14 10:49
Citation álvarez-Chaver P, Otero-Estévez O, Páez de la Cadena M, Rodríguez-Berrocal FJ, Martínez-Zorzano VS. Proteomics for discovery of candidate colorectal cancer biomarkers. World J Gastroenterol 2014; 20(14): 3804-3824
URL http://www.wjgnet.com/1007-9327/full/v20/i14/3804.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i14.3804
Full Article (PDF) WJG-20-3804.pdf
Full Article (Word) WJG-20-3804.doc
Manuscript File 6643-Review.doc
Answering Reviewers 6643-Answering reviewers.pdf
Copyright License Agreement 6643-Copyright assignment.pdf
Peer-review Report 6643-Peer review(s).pdf
Scientific Editor Work List 6643-Scientific editor work list.doc