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8/26/2014 2:46:00 PM | Browse: 1191 | Download: 1029
Publication Name World Journal of Gastroenterology
Manuscript ID 6663
Country/Territory Türkiye
Received
2013-10-26 16:50
Peer-Review Started
2013-10-27 12:58
To Make the First Decision
2014-01-09 12:32
Return for Revision
2014-01-11 19:24
Revised
2014-02-08 23:19
Second Decision
2014-05-26 16:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-26 16:38
Articles in Press
2014-05-26 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-06-04 15:22
Publish the Manuscript Online
2014-06-21 13:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update
Manuscript Source Invited Manuscript
All Author List Gülsüm Özlem Elpek
Funding Agency and Grant Number
Corresponding Author Gülsüm Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Pinarbasi Mh., 07070 Antalya, Turkey. elpek@akdeniz.edu.tr
Key Words Liver; Liver fibrosis; Cirrhosis; Fibrogenesis; Hepatic stellate cells; Myofibroblast; Extracellular matrix
Core Tip Liver fibrosis is a dynamic process that results from an imbalance between the production and dissolution of the extracellular matrix. Development of liver fibrosis is orchestrated by many cell types, including hepatic stellate cells (HSCs). The activation of HCSs is a complex process, leading to multiple potential sites for therapeutic interventions. Additionally, the differences between the pathogenesis of liver fibrosis associated with different etiologies may provide the determination of new therapeutic approaches. This review summarizes the most significant data that has contributed to the understanding of the cellular and molecular pathogenesis of liver fibrosis, which may be translated into future therapeutic strategies.
Publish Date 2014-06-21 13:56
Citation Elpek GO. Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update. World J Gastroenterol 2014; 20(23): 7260-7276
URL http://www.wjgnet.com/1007-9327/full/v20/i23/7260.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i23.7260
Full Article (PDF) WJG-20-7260.pdf
Full Article (Word) WJG-20-7260.doc
Manuscript File 6663-Review.doc
Answering Reviewers 6663-Answering reviewers.pdf
Copyright License Agreement 6663-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 6663-Language certificate.pdf
Peer-review Report 6663-Peer review(s).pdf
Scientific Misconduct Check 6663-CrossCheck.jpg
Scientific Editor Work List 6663-Scientific editor work list.pdf